Anonymous ID: 8e185f Nov. 16, 2021, 8:15 a.m. No.15012051   🗄️.is 🔗kun

https://www.acpjournals.org/doi/10.7326/L21-0297

A Possible Sterilizing Cure of HIV-1 Infection Without Stem Cell Transplantation

A sterilizing cure of HIV-1 infection has been reported in 2 persons living with HIV-1 who underwent allogeneic hematopoietic stem cell transplantations from donors who were homozygous for the CCR5Δ32 gene polymorphism. However, this has been considered elusive during natural infection.

 

Genome-intact and replication-competent HIV-1 were not detected in an elite controller despite analysis of massive numbers of cells from blood and tissues, suggesting that this patient may have naturally achieved a sterilizing cure of HIV-1 infection. These observations raise the possibility that a sterilizing cure may be an extremely rare but possible outcome of HIV-1 infection.

Primary Funding Source:

National Institutes of Health and Bill & Melinda Gates Foundation.