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>biofilms from earlier today…
Biofilm inhibition effect of an ivermectin/silyl acrylate copolymer coating and the colonization dynamics
Ivermectin is now being used as a substitute for toxic organic biocide in marine antifouling coatings due to its environmentally friendly nature and the efficacy against parasites. However, the release performance of ivermectin from the hydrolyzed acrylic-based resin into the seawater is not clear. Moreover, the efficiency and mechanism of ivermectin in preventing biofilm or slime formation have not been fully investigated. In this study, a coating was developed by mixing ivermectin with an acrylic-based resin, silyl acrylate copolymer, and a 45-day in situ antifouling test was conducted in the Yellow Sea. Direct observation and confocal microscope investigation indicated that the polymer coating with ivermectin was effective against biofilm formation. High-throughput sequencing analysis showed that ivermectin can selectively inhibit the adhesion of microorganisms. Abundances of Gammaproteobacteria and Alphaproteobacteria decreased significantly with the increased concentration of ivermectin. As for the eukaryote community, species of Stolidobranchia and unidentified_Bacillariophyceae were proved to be sensitive to ivermectin. Therefore, the ivermectin/silyl acrylate copolymer coating is a promising substitute for marine antifouling material.