Anonymous ID: 2044ec Nov. 19, 2021, 11 a.m. No.15036101   🗄️.is 🔗kun   >>6121

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8557950/

https://archive.md/IqtfH

 

Spectrum of neurological complications following COVID-19 vaccination

 

Abstract

COVID-19 vaccines have brought us a ray of hope to effectively fight against deadly pandemic of COVID-19 and hope to save lives. Many vaccines have been granted emergency use authorizations by many countries. Post-authorization, a wide spectrum of neurological complications is continuously being reported following COVID-19 vaccination. Neurological adverse events following vaccination are generally mild and transient, like fever and chills, headache, fatigue, myalgia and arthralgia, or local injection site effects like swelling, redness, or pain. The most devastating neurological post-vaccination complication is cerebral venous sinus thrombosis. Cerebral venous sinus is frequently reported in females of childbearing age, generally following adenovector-based vaccination. Another major neurological complication of concern is Bell’s palsy that was reported dominantly following mRNA vaccine administration. Acute transverse myelitis, acute disseminated encephalomyelitis, and acute demyelinating polyneuropathy are other unexpected neurological adverse events that occur as result of phenomenon of molecular mimicry. Reactivation of herpes zoster in many persons, following administration of mRNA vaccines, has been also recorded. Considering the enormity of recent COVID-19-vaccinated population, the number of serious neurological events is miniscule. Large collaborative prospective studies are needed to prove or disprove causal association between vaccine and neurological adverse events occurring vaccination.

 

Conclusion

Post-authorization, a wide spectrum of serious neurological complications has been reported following COVID-19 vaccination. The most devastating neurological complication is cerebral venous sinus thrombosis that has been reported in females of childbearing age following adenovector-based vaccines. Another major neurological complication of concern is Bell’s palsy that was reported dominantly following mRNA vaccine administration. Transverse myelitis, acute disseminated encephalomyelitis, and Guillain-Barré syndrome are other severe unexpected post-vaccination complications that can occur as result of molecular mimicry and subsequent neuronal damage. Most of other serious neurological complications are reported in either in form of isolated case reports or small cases series. A causal association of these adverse events is controversial; large collaborative prospective studies are needed to prove causality.

Anonymous ID: 2044ec Nov. 19, 2021, 11:02 a.m. No.15036121   🗄️.is 🔗kun

>>15036101

https://onlinelibrary.wiley.com/doi/10.1111/ane.13550

https://archive.md/TUI9o

 

Neurological side effects of SARS-CoV-2 vaccinations

 

Abstract

SARS-CoV-2 and adverse reactions to SARS-CoV-2 vaccinations show a tropism for neuronal structures and tissues. This narrative review was conducted to collect and discuss published data about neurological side effects of SARS-CoV-2 vaccines in order to discover type, frequency, treatment, and outcome of these side effects. The most frequent neurological side effects of SARS-CoV-2 vaccines are headache, Guillain-Barre syndrome (GBS), venous sinus thrombosis (VST), and transverse myelitis. Other neurological side effects occur in a much lower frequency. Neurological side effects occur with any of the approved vaccines but VST particularly occurs after vaccination with vector-based vaccines. Treatment of these side effects is not at variance from similar conditions due to other causes. The worst outcome of these side effects is associated with VST, why it should not be missed and treated appropriately in due time. In conclusion, safety concerns against SARS-CoV-2 vaccines are backed by an increasing number of studies reporting neurological side effects. The most frequent of them are headache, GBS, VST, and transverse myelitis. Healthcare professionals, particularly neurologists involved in the management of patients having undergone SARS-CoV-2 vaccinations, should be aware of these side effects and should stay vigilant to recognize them early and treat them adequately.

 

3 RESULTS

Neurological side effects of SARS-CoV-2 vaccines collected from the literature are listed in Table 1. They include headache, Guillain-Barre syndrome (GBS), venous sinus thrombosis (VST), transverse myelitis, facial nerve palsy, small fiber neuropathy, newly developing multiple sclerosis, and some others that have been reported only in a few patients (Table 1). By far the most frequent of the neurological adverse reactions to SARS-CoV-2 vaccinations is headache, followed by GBS, VST, and myelitis (Table 1). Neurological side effects develop after any of the commercially available anti-COVID-19 vaccines but myelitis predominantly after application of the AstraZeneca vaccine (AZV).