Copa Airlines Flight 201 was a regularly scheduled passenger flight from Tocumen International Airport in Panama City, Panama to Alfonso Bonilla Aragón International Airport in Cali, Colombia. On 6 June 1992, the Boeing 737-204 Advanced operating the route flipped, disintegrated in mid-air, and crashed into the Darien Gap 29 minutes after takeoff, killing all 47 people on board. The in-flight break-up was caused by faulty instrument readings and several other contributing factors, including incomplete training.
Flight 201 is the deadliest accident in Panamanian aviation history, and also the first (and to date, only) fatal crash in the history of Copa Airlines.
https:// en.wikipedia.org/wiki/Copa_Airlines_Flight_201