It's a cascade effect.
The body's primary way of expelling waste and toxins is through the respiratory system. When that gets impeded, it falls onto the kidneys. And since most people don't drink nearly enough water, they end up dehydrating because of all the pissing they have to do.. Dehydration causes all sorts of cognitive issues. Now project that daily issue out over nearly two years. It's no wonder people are acting and looking so horrible.