Anonymous ID: cd0896 Dec. 22, 2021, 3:37 a.m. No.15236019   🗄️.is 🔗kun   >>6036 >>6038 >>6051

https://nypost.com/2021/12/21/cuomos-ex-cnn-producer-john-griffin-tried-to-pay-off-sex-crimes-witness-feds/

Chris Cuomo’s former CNN producer John Griffin tried to pay off sex crimes witness: feds

Fired CNN producer John Griffin tried to “deceive, delete, and spend his way out of being held accountable” for his alleged sex crimes against a minor, new court documents allege.

Griffin, 44, was indicted this month by a federal grand jury in Vermont for attempting to “induce minors to engage in unlawful sexual activity,” and allegedly bragged about luring girls as young as 7 to his home for “sexual subservience” training.

The former producer who boasted about working “shoulder to shoulder” with Chris Cuomo was fired by CNN following his arrest and is facing up to 10 years in prison for each of the three counts he is facing in charges involving a 9-year-old girl.

In a motion to keep him in jail until his trial, US Attorney Nikolas P. Kerest said Griffin’s detention is crucial to community safety. He is “a wealthy man who is desperate to avoid facing justice” with a history of mental illness, substance abuse and alleged sexual assault of minor, Kerest said, who cited Jeffrey Epstein court docs in the motion.

The motion, filed Monday, offers more details about Griffin’s alleged actions, including that he offered a woman $30,000 in January 2020 for a mother-and-daughter getaway. In March 2020, he offered another woman $1,200 for sex, saying he would up the payment to $5,000 “if the kids are in the room,” the feds said.

When chatting with someone online who admitted to sexually assaulting a baby, Griffin reassured the assailant, saying, “You need to promise me that you will always understand what you’re doing is right, OK?” Chats show him calling young girls and babies explicit names like “little slut,” “little whore,” and “little b—h.”

He also sent $4,000 via Venmo to a family member of the 9-year-old he is accused of assaulting as part of an “apparent pay-off,” according to the feds.

Prosecutors said in their complaint that Griffin, of Stamford, Connecticut, attempted to lure at least four girls, ages 16, 14, 13 and 9, to his Vermont ski house for “training sessions” on such things as “spanking” and “c–k worship,” reportedly saying a “woman is a woman regardless of her age.”

Griffin allegedly told Heather Carriker, a mother of two daughters, that she needed to ensure her girls were “trained properly,” the DOJ said. Then, in July 2020, he allegedly gave Carriker $3,000 to fly with her 9-year-old from their home in Henderson, Nevada, to Boston, where he picked the two up and brought them to his $2.5 million Vermont mansion. During the visit, “the daughter was directed to engage in, and did engage in, unlawful sexual activity,” the DOJ said, that Carriker, 48, was also a part of.

Carriker, 48, was arrested on August 21, 2020, on two counts of child abuse, two counts of sexual assault against a child under 14 and one count of lewdness with a minor under 14.

The allegations came to light when the child’s biological mother, Catherine O’Sullivan, who sometimes took care of her daughter, discovered explicit text messages of Carriker’s involving the young girl.

Feds said in the Monday filing that “there is no set of conditions that can assure the Court of [Griffin’s] continued appearance or address the danger he presents if released.”

“He has dishonestly tried to talk his way out of being held accountable. He has tried to buy his way out of trouble,” they wrote.

Griffin is married with three children under the age of 18. His wife rescinded her letter of support of him in August 2021. He told feds he has estate worth $35 million to $40 million and used to own a 44-foot yacht.

“Unlike the overwhelming majority of criminal defendants who come before the Court, Griffin has enjoyed rarified privilege and a place in wealthy society. He faces not only a substantial loss of liberty, but also extraordinary reputational loss. It appears he has no law-abiding community to return to,” the motion said. “Griffin not only has an incentive to flee, he also has the means to.”

Anonymous ID: cd0896 Dec. 22, 2021, 3:47 a.m. No.15236031   🗄️.is 🔗kun

https://nypost.com/2021/12/22/former-virginia-governor-chuck-robbs-mansion-suffers-massive-fire/

Former Virginia governor Chuck Robb’s mansion turns into flaming inferno

Former Governor Chuck Robb’s Virginia mansion went up in flames late Tuesday night.

Firefighters arrived at the two-alarm fire on the 600 block of Chain Bridge Road in McLean, Va. at 11:30 p.m. The fire had spread throughout the home’s first floor.

Two people escaped the home and were transported to the hospital with non-life-threatening injuries, according to Fairfax County Fire and Rescue.

There’s no indication if the people were Robb and his wife Lynda, daughter of former President Lyndon B. Johnson.

Fairfax Fire officials announced the fire was under control following the three-hour battle.

Investigators have yet to determine the cause of the blaze.

https://twitter.com/ffxfirerescue/status/1473552060511670272

Anonymous ID: cd0896 Dec. 22, 2021, 3:50 a.m. No.15236038   🗄️.is 🔗kun

>>15236019

https://www.8newsnow.com/news/i-team-henderson-woman-charged-with-sex-crimes-in-case-involving-cnn-producer/

I-Team: Henderson woman charged with sex crimes in case involving CNN producer

CNN producer paid Nevada woman to fly cross-country last year, prosecutors say

A Henderson woman is facing charges for her alleged role in an incident where a CNN producer paid her to travel cross-country with a child for sex, police confirmed Tuesday.

Henderson police arrested Heather Carriker, 48, in August 2020, a spokesperson for the department confirmed.

Carriker was charged with two counts of child abuse, two counts of sexual assault against a child under 14 and one count of lewdness with a minor under 14.

The FBI took John Griffin, 44, of Stamford, Connecticut, into custody last week for charges connected to enticing minor to engage in unlawful sexual activity.

Griffin has worked at CNN for 8 years, the network confirmed Saturday.

Griffin used online messaging services Kik and Google Hangouts to talk to people reportedly being parents of young girls, saying, among other things, that young women should be trained to “be sexually subservient and inferior to men,” prosecutors wrote in a news release.

Investigators allege Griffin transferred $3,000 to Carriker so she could buy plane tickets from Nevada to Boston for her and a child.

According to court documents, Carriker is accused of engaging in sex acts with Griffin and a minor.

Carriker’s next court hearing was scheduled for Dec. 22 in Henderson Justice Court.

Because Griffin’s case is in federal court, no booking photo was available.

Anonymous ID: cd0896 Dec. 22, 2021, 3:54 a.m. No.15236046   🗄️.is 🔗kun

Barack Obama and his two daughters were spotted lapping up the ocean over the weekend after heading to Hawaii for their annual family Christmas vacation.

Anonymous ID: cd0896 Dec. 22, 2021, 3:55 a.m. No.15236049   🗄️.is 🔗kun   >>6096

https://twitter.com/BetteMidler/status/1472955243935711236

 

What #JoeManchin, who represents a population smaller than Brooklyn, has done to the rest of America, who wants to move forward, not backward, like his state, is horrible. He sold us out. He wants us all to be just like his state, West Virginia. Poor, illiterate and strung out.

Anonymous ID: cd0896 Dec. 22, 2021, 3:57 a.m. No.15236052   🗄️.is 🔗kun   >>6115

During a press conference before Biden unveiled his testing ramp up Tuesday, Psaki was asked the exchange where she dismissed an NPR reporter’s inquiry about simplifying Biden’s plan to provide 150 million free tests to Americans.

“Should we just send one to every American?” she had snapped when pressed about the process of providing refunds to those who bought tests.

On Tuesday, amid Biden’s plan to offer half-a-billion home test kits to Americans for free Psaki was asked by a CNN reporter if she regretted her tone.

“I would say there’s not a day that goes by that I don’t leave this podium and wish I would have said something with greater context or more precision or additional information,” the spokeswoman said.

Anonymous ID: cd0896 Dec. 22, 2021, 4:02 a.m. No.15236065   🗄️.is 🔗kun   >>6066

https://nypost.com/2021/12/21/religious-saints-of-murders-outlaws-worshiped-by-cartels/

Santa Muerte and five more ‘religious’ saints worshiped by drug cartels

Santa Muerte has a fondness for tequila, cigarettes, candy — and human blood.

The saint is a favorite of Mexican and Central American drug traffickers who are known to leave the severed heads of their enemies at improvised shrines, featuring wax effigies and votive candles emblazoned with the skeletal image of the one also known as Holy Death.

Dressed in a flowing white robe and often wielding both a scythe and a globe, Santa Muerte — a cross between the Grim Reaper and the Virgin of Guadeloupe, Mexico’s patron saint — is just one of a rapidly growing religious movement of “narco saints,” worshiped by drug traffickers who pray to them for protection, riches and the silence necessary to mask their underworld dealings.

“The narcos and the gangs all believe in the power of prayer,” said Robert Almonte, a Texas-based security consultant and former deputy chief of the El Paso Police Department who specialized in narcotics. “They believe that the saints will protect them no matter what they do — and that’s dangerous because it emboldens the traffickers who truly believe they can get away with murder and still go to heaven.”

The movement is growing, with estimates of up to 12 million devotees in Mexico and, now, parts of the US. American law enforcement officials struggling under the recent wave of illegal migrant crossings are increasingly documenting altars to the macabre saint — and another, Jesus Malverde — in stash houses in US border communities where Mexican drug cartel members often hold migrants for ransom, Almonte said.

Not that these saints are canonized. The Catholic Church has condemned Santa Muerte worship as “blasphemous and Satanic.” When Pope Francis visited Mexico for the first time in 2016, he condemned the cult, which is one of the fastest growing new “religious” movements in the world, according to the Catholic Herald.

“I am particularly concerned about those many persons who, seduced by the empty power of the world, praise illusions and embrace their macabre symbols to commercialize death in exchange for money,” the Pope said, referring to Santa Muerte. “I urge you not to underestimate the moral and antisocial challenge which the drug trade represents for Mexican society as a whole, as well as for the Church.”

Altars to Santa Muerte are created in private homes, with larger statues erected in public squares in impoverished parts of Mexico. There is also a Santa Muerte sanctuary, with several life-sized effigies of the saint, in an industrial area of Las Vegas.

In some cases, Santa Muerte altars feature bundles of cash offerings, which are considered sacrosanct. Rival narcos — including members of the notorious MS-13 gang from El Salvador — know not to touch the money for fear of enduring the saint’s wrath, law enforcement officials say.

Many of the gruesome murders, including beheadings and human sacrifices, committed by Mexican drug gangs are done so in the name of Santa Muerte, said Almonte, who is writing a book about the cult.

In a 2016 interview, a sicario for the Juarez Cartel named Edgar described his worship, telling documentary filmmakers during a prison interview that, before each hit job, he would pray to the saint to ensure that everything would go according to plan.

“I actually sacrifice people for my Santa Muerte,” said Edgar, then 26. “The thing is that I kill for ordering, but I talk to her and say, ‘Hey, I go to a job. Just make me hit, I am gonna give you that life, it is for you.’” Edgar claimed he had killed 60 people on the orders of the Juarez Cartel.

Anonymous ID: cd0896 Dec. 22, 2021, 4:03 a.m. No.15236066   🗄️.is 🔗kun   >>6068

>>15236065

>“I actually sacrifice people for my Santa Muerte,” said Edgar, then 26. “The thing is that I kill for ordering, but I talk to her and say, ‘Hey, I go to a job. Just make me hit, I am gonna give you that life, it is for you.’” Edgar claimed he had killed 60 people on the orders of the Juarez Cartel.

The Santa Muerte cult traces its roots to colonial-era Mexico when devotees worshiped the folk deity in secret after the Catholic Church had banned the practice. The cult gained prominence in the 1940s and then again in 2001 when a street vendor named Queta Romero mounted an outdoor shrine to Santa Muerte in Tepito, one of Mexico’s City’s most violent neighborhoods. Thousands came to worship at the shrine — including women who prayed to the saint to make their husbands’ mistresses disappear.

Almonte, who is a former federal marshal, has been documenting the Santa Muerte cult since 1985 and spent the last several years crisscrossing the country, lecturing US law enforcement about Santa Muerte as well as a pantheon of other narco saints — including Jesus Malverde, a mustachioed Robin Hood-like bandit revered among the Sinaloa Cartel and considered the patron saint of drug traffickers in Mexico.

During jury selection at the 2018 trial of former Sinaloa Cartel chief Joaquin “El Chapo” Guzman in Brooklyn federal court, potential jurors were asked if they were familiar with Jesus Malverde, a legendary figure of pre-Revolution Mexico.

Jesus Malverde and Santa Muerte are often honored together in ceremonies throughout Mexico, although human sacrifices are not offered to Malverde, cartel experts told The Post.

In January, 2010, a trafficker placed a decapitated head next to the tomb of legendary cartel leader Arturo Beltran Leyva, who had been killed in his apartment surrounded by Santa Muerte paraphernalia. The suggestion was that the drug dealer had placed the severed head next to the grave as an offering to Santa Muerte, experts said.

“When we see a deep criminal Santa Muerte connection it’s about the gaining of some

sort of favor [vast riches or the death of an enemy] or supernatural powers [spiritual armor] via the reaping of a soul,” Robert Bunker, a security consultant and University of Southern California instructor, told The Post. “Sometimes this is ritualized and other times it is not.”

Authorities have also documented a handful of Santa Muerte-influenced murders on the US side of the border, including a 2010 beheading in Chandler, Ariz. Cook County prosecutors in Chicago documented 13 Santa Muerte-affiliated murders between 2009 and 2011 by cartel kill teams. One killing crew had Santa Muerte stickers on their vehicles, tattoos on their bodies, altars in their homes and Santa Muerte-stamped bands to hold their cash, the Chicago Tribune reported.

In 2012, the cult made headlines in Mexico when one of its self-proclaimed high priests, David Romo Guillén, was sentenced to 66 years in prison for kidnapping and extortion. Earlier, he had called for holy war against the Catholic Church. Most of the Santa Muerte adherents live in Mexico, and the vast majority are not as hardcore as drug trafficker devotees, worshiping the folk deity without resorting to any acts of violence.

According to Bunker, who has also worked with the FBI’s Behavioral Science Unit, “A component of the cartel and gang members have gone down the path of ‘dark’ Santa Muerte worship as opposed to more benign Santa Muerte veneration” — which represents the vast majority of adherents in general society and also criminal groups who may be into SM “lite.”

Almonte recalled being approached by a police officer who was not able to crack a difficult homicide case until finding a note — written by a suspect seeking protection — at the crime scene.

“She would only have written that if she needed protection from us,” said the officer in an email to Almonte that was viewed by The Post. “She then broke down and told us about how the suspect used her rental car to commit the murder and that the prayer was written to help them from getting caught.”

As cartels continue to make inroads into the US, Santa Muerte-influenced violence is expected to increase, experts say.

“What I tell the officers when I am training them is that the cartel guys are doing this in Mexico and they will continue to do the same things here,” Almonte said. “It’s going to get worse here.”

Anonymous ID: cd0896 Dec. 22, 2021, 4:10 a.m. No.15236081   🗄️.is 🔗kun   >>6103

>>15236051

>“Unlike the overwhelming majority of criminal defendants who come before the Court, Griffin has enjoyed rarified privilege and a place in wealthy society. He faces not only a substantial loss of liberty, but also extraordinary reputational loss. It appears he has no law-abiding community to return to,” the motion said. “Griffin not only has an incentive to flee, he also has the means to.”

just one of the boys

Anonymous ID: cd0896 Dec. 22, 2021, 5:22 a.m. No.15236234   🗄️.is 🔗kun

>>15236217

>That being said, anons have a 2% head start and ‘cracking the shell’ for real normies to just think for themselves seems to be the hardest part. That ‘shell’ is made of 17’ thick reinforced concrete.

We can help. They can't think for themselves cause they're too busy chasing the carrot. I dunno about you, but circumstance brought me here.

Anonymous ID: cd0896 Dec. 22, 2021, 6:08 a.m. No.15236429   🗄️.is 🔗kun   >>6439

https://www.timesofisrael.com/80-years-ago-how-a-very-different-schindlers-list-helped-ignite-wwii/

80 years ago, how a very different Schindler’s ‘list’ helped ignite WWII

Controlling up to two dozen German spies, Oskar Schindler helped stage the false-flag ‘Gleiwitz Incident’ to justify Germany’s invasion of Poland

KRAKOW, Poland — Oskar Schindler shielded 1,200 Jewish factory workers during the Holocaust and a Hollywood movie about the heroic rescue has turned his name into the archetype for a Righteous Among the Nations. However, the Nazi-turned-savior also played less altruistic roles during Hitler’s rule.

Ignored by the book and film bearing his name, Schindler helped Germany lay groundwork for its invasion of Poland 80 years ago. Leading up to the blitzkrieg attack launched on September 1, 1939, Schindler led a network of 25 spies and prepared an infamous false-flag attack called the “Gleiwitz Incident.”

By all accounts, Schindler during the mid-30s was “unemployed and frustrated,” not to mention an alcoholic who owed many debts. He racked up criminal charges and prison stints, including for brawling, dangerous threats, and swindling. Schindler’s failed gigs ranged from poultry farming to banking, and he was known as “Schindler Swindler.”

During a series of high-society parties, Schindler impressed the right Nazi spy masters. One of them recruited him into Germany’s Abwehr (military intelligence), and Schindler was sent to Ostrava in today’s Czech Republic. Located near the border with Poland, the city was a hotbed of agents and double-agents.

Contrary to the suave manipulator portrayed in the film “Schindler’s List,” the 30 year old’s first stint as a spy was comical. People in Ostrava knew Schindler by name and he did not bother to change his address, all while gathering information on Czech military defenses. This carelessness led to Schindler’s arrest with the charge of capital offenses against the Czech state.

In August of 1938, Schindler pleaded guilty and was sentenced to death during court proceedings in Brno. However, Germany moved into the Sudetenland two months later, and all political prisoners — including Schindler — were pardoned and freed.

Details about this period in Schindler’s life did not emerge until after the book and film made him a legend. Fifteen years ago, David M. Crowe provided much of the backstory in his book, “Oskar Schindler: The Untold Account of his Life, Wartime Activities, and the True Story Behind the List.”

Among the activities described by Crowe in the book, Schindler once brought home cages of pigeons to the apartment he shared with his wife Emilie. The birds were intended to carry messages, but Schindler lost interest in them. He seemed to have internalized lessons from his botched first spy gig, however, and adopted code names including Otto and Schofer.

Important for Schindler’s career and future ability to rescue Jews, he received a promotion in the Abwehr: deputy commander of intelligence for the region surrounding Ostrava. Close to his territory was the German town Gleiwitz — Gliwicz in today’s Poland — with its 14th century castle.

Gleiwitz was also home to Europe’s tallest wooden structure, a radio tower completed in 1935. At 118 meters, the structure was called “The Silesian Eiffel Tower” around town, and its location near the border made it a powerful propaganda tool.

After officially joining the Nazi party in 1939, Schindler was called upon to prepare a false-flag attack related to the Gleiwitz tower. The borderlands were fueled with anti-Polish propaganda, and Schindler would help light one of many matches.

Anonymous ID: cd0896 Dec. 22, 2021, 6:11 a.m. No.15236439   🗄️.is 🔗kun   >>6444

>>15236429

A gift for charming news out of people

“On his Polish journey for the Abwehr, he showed a gift for charming news out of people, especially in a social setting — at the dinner table, over cocktails,” wrote Keneally. “We do not know the exact importance of what he found out [for his handlers], but he came to like the city of Krakow very well,” wrote the author.

In Keneally’s book, the entirety of Schindler’s three-year spy career was reduced to a few paragraphs. According to Abwehr records, however, Schindler ran surveillance of key transportation routes and smuggled fighters and weapons across the border into Poland. At his peak, two-dozen field operatives reported to him with intelligence.

Contrary to the film portrayal of Schindler entering Krakow on the heels of the German army, he started eyeing businesses and homes there before the invasion of Poland. During the period that Schindler was getting to know Krakow, his agents were gathering supplies for the coming false-flag attack at Gleiwitz — Polish army uniforms? Check. Weapons? Check. Polish cigarettes? Check.

Collectively, the false-flag operations and anti-Polish propaganda were called “Operation Himmler.” One week before the planned invasion of Poland, Hitler warned his generals about the “propagandistic casus belli” being prepared, assuring them the “credibility” of any “justifications” for invading Poland would not be questioned after Germany’s ultimate victory.

In keeping with Heinrich Himmler’s penchant for exploiting concentration camp prisoners, a number of them were murdered to stage the border incidents. After being dressed in Polish uniforms, the victims — known as “canned goods” — were given lethal injections and gunfire wounds. Their corpses were displayed at several strategic installations near the border as proof of Poland’s aggression.

For the Gleiwitz operation, a German farmer known for sympathizing with Poland was murdered and his corpse left out for the press to photograph. He was meant to be the Polish “attacker” of the famous radio tower, killed by its German defenders. A fake Polish-language radio announcement about capturing the radio tower was heard with alarm by millions of Germans.

Within hours of the operation at Gleiwitz, the foreign press was invited to inspect the bloody scene at the radio tower. Media outlets everywhere led with Poland’s aggression against Germany, and the truth did not come out until 1945 at Nuremberg.

Anonymous ID: cd0896 Dec. 22, 2021, 6:12 a.m. No.15236444   🗄️.is 🔗kun   >>6476

>>15236439

He was always in the con game

In the film “Schindler’s List,” the protagonist pins a swastika onto his lapel before we even see his face. That quick gesture can be said to fill in for Schindler’s three years as an Abwehr saboteur and his role in “Operation Himmler,” for which both the Polish and Czech governments declared him a war criminal.

Filmmaker Steven Spielberg became aware of Schindler’s Abwehr career while making “Schindler’s List,” released in 1993. In an interview with “Inside Film” that year, the “E.T.” director called Schindler, “the man who perpetrated the con that gave Hitler the excuse to invade Poland.”

According to Spielberg, “[Schindler] was always in the con game.” His role in the Gleiwitz incident, said Spielberg, was about Schindler crafting a “little piece of prefabricated history.”

When David Crowe published his image-shattering biography of Schindler in 2004, the book was praised for “taking the shine off Spielberg’s Schindler.” The late survivor and Nobel-laureate Elie Wiesel hailed Crowe in The New York Times for “complicating” the story of Schindler and making him “more human, and also more extraordinary.”

The Keneally book and Spielberg film are not the only Schindler accounts to omit the leading man’s sabotage activities. According to Schindler’s biography on Yad Vashem’s website, “Shortly after the outbreak of war in September, thirty-one-year-old Schindler showed up in occupied Krakow.”

On Yad Vashem’s website and most other Holocaust memory websites with Schindler content, there is no mention of his role in the Abwehr. Although Schindler’s pre-invasion espionage activities gave him the know-how and SS contacts to enact a wide-scale rescue of Jews, that backstory is usually absent from accounts of his life.

Schindler continued his intelligence work until 1940, when he was sent to Turkey to investigate employees of the German Embassy. By then, he was firmly on top of operations at a formerly Jewish-owned enamelware factory in Krakow. Soon, Schindler would apply skills honed in the Abwehr to transform the factory into an ark for 1,200 Jewish workers.

Anonymous ID: cd0896 Dec. 22, 2021, 6:19 a.m. No.15236476   🗄️.is 🔗kun

>>15236444

>Oskar Schindler

“The man who perpetrated the con that gave Hitler the excuse to invade Poland.”

  • Steven Spielberg 1993

 

His role in the Gleiwitz incident was about Schindler crafting a “little piece of prefabricated history” said Spielberg.

Anonymous ID: cd0896 Dec. 22, 2021, 6:25 a.m. No.15236516   🗄️.is 🔗kun   >>6523

https://www.army.mil/article/252890/series_of_preclinical_studies_supports_the_armys_pan_coronavirus_vaccine_development_strategy

Series of preclinical studies supports the Army’s pan-coronavirus vaccine development strategy

SILVER SPRING, Md. – A series of recently published preclinical study results show that the Spike Ferritin Nanoparticle (SpFN) COVID-19 vaccine developed by researchers at the Walter Reed Army Institute of Research (WRAIR) not only elicits a potent immune response but may also provide broad protection against SARS-CoV-2 variants of concern as well as other coronaviruses.

Scientists in WRAIR’s Emerging Infectious Diseases Branch (EIDB) developed the SpFN nanoparticle vaccine, based on a ferritin platform, as part of a forward-thinking “pan-SARS” strategy that aims to address the current pandemic and acts as a first line of defense against variants of concern and similar viruses that could emerge in the future.

“The accelerating emergence of human coronaviruses throughout the past two decades and the rise of SARS-CoV-2 variants, including most recently Omicron, underscore the continued need for next-generation preemptive vaccines that confer broad protection against coronavirus diseases,” said Dr. Kayvon Modjarrad, Director of the Emerging Infectious Diseases Branch at WRAIR, co-inventor of the vaccine and the U.S. Army lead for SpFN. “Our strategy has been to develop a ‘pan-coronavirus’ vaccine technology that could potentially offer safe, effective and durable protection against multiple coronavirus strains and species.”

Pre-clinical studies published today in Science Translational Medicine indicate that the SpFN vaccine protects non-human primates from disease caused by the original strain of SARS-CoV-2 and induces highly-potent and broadly-neutralizing antibody responses against major SARS-CoV-2 variants of concern including the SARS-CoV-1 virus that emerged in 2002.

SpFN entered Phase 1 human trials in April 2021. Early analyses, expected to conclude this month, will provide insights into whether SpFN’s potency and breadth, as demonstrated in preclinical trials, will carry over into humans. The data will also allow researchers to compare SpFN’s immune profile to that of other COVID-19 vaccines already authorized for emergency use.

“This vaccine stands out in the COVID-19 vaccine landscape,” Modjarrad said. “The repetitive and ordered display of the coronavirus spike protein on a multi-faced nanoparticle may stimulate immunity in such a way as to translate into significantly broader protection.”

WRAIR developed a secondary candidate vaccine, a SARS-CoV-2 Spike Receptor-Binding Domain Ferritin Nanoparticle (RFN) vaccine, which targets a smaller part of the coronavirus Spike protein than the SpFN vaccine. Results from a study, published recently in the Proceedings of the National Academy of Sciences, show that this vaccine potentially offers similar protection against an array of SARS-CoV-2 variants and SARS-CoV-1.

“The RFN vaccine candidate is more compact and has some natural advantages as we try to increase the immune response against multiple coronaviruses using a single vaccine platform, so it is still under consideration as part of our pan-coronavirus vaccine development pipeline,” said WRAIR structural biologist and vaccine co-inventor, Dr. Gordon Joyce.

“The threat from COVID-19 continues as it evolves, and eventually there will be other emerging disease threats,” said Dr. Nelson Michael, Director of the Center for Infectious Diseases Research at WRAIR. “Our investment in developing a next generation vaccine is an important step towards getting ahead of COVID-19 and future disease threats.”

Anonymous ID: cd0896 Dec. 22, 2021, 6:26 a.m. No.15236523   🗄️.is 🔗kun

>>15236516

A SARS-CoV-2 Ferritin Nanoparticle Vaccine Elicits Protective Immune Responses in Nonhuman Primates

http://www.science.org/doi/10.1126/scitranslmed.abi5735

 

Efficacy and breadth of adjuvanted SARS-CoV-2 receptor-binding domain nanoparticle vaccine in macaques

https://www.pnas.org/content/118/38/e2106433118

 

SARS-CoV-2 ferritin nanoparticle vaccine induces robust innate immune activity driving polyfunctional spike-specific T cell responses

https://www.nature.com/articles/s41541-021-00414-4

 

A SARS-CoV-2 spike ferritin nanoparticle vaccine protects against heterologous challenge with B.1.1.7 and B.1.351 virus variants in Syrian golden hamsters

https://www.nature.com/articles/s41541-021-00392-7

 

SARS-CoV-2 ferritin nanoparticle vaccines elicit broad SARS coronavirus immunogenicity

https://www.cell.com/cell-reports/fulltext/S2211-1247(21)01639-9

 

SARS-COV-2-Spike-Ferritin-Nanoparticle (SpFN) Vaccine With ALFQ Adjuvant for Prevention of COVID-19 in Healthy Adults

Clinical Trials.gov: https://clinicaltrials.gov/ct2/show/NCT04784767