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Anonymous ID: 4a4c39 Dec. 23, 2021, 7:52 p.m. No.15246305   🗄️.is 🔗kun   >>6331

Spike Ferritin Nanoparticle

 

Self-assembling protein nanoparticle vaccines offer the advantage of multivalent antigen presentation, a property previously shown to augment immunogenicity over monovalent immunogens (5–7). Ferritin is a naturally occurring, ubiquitous, iron-carrying protein that self-oligomerizes into a 24-unit spherical particle (8). The three-fold axis symmetry of the resulting polymer makes it conducive to conjugation and antigen display of trimeric glycoproteins, such as SARS-CoV-2 spike protein. Ferritin has been evaluated as a vaccine platform for several pathogens (9–11), most notably influenza, for which it has demonstrated immune potency and breadth (12, 13). As such, ferritin vaccines have advanced to phase 1 clinical trials as a strategy to target multiple influenza strains (14, 15).