dChan
Anonymous ID: d69d70 Dec. 29, 2021, 7:35 a.m. No.15272378   🗄️.is 🔗kun   >>2402 >>2442 >>2884

https://twitter.com/JackPosobiec/status/1476103936474066945?s=20

 

RESEARCH BRIEFINGS

23 December 2021

Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift

Elisabetta Cameroni , John E. Bowen , … Davide Corti Show authors

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ADVANCE ARTICLE PREVIEW

This manuscript has been peer reviewed and accepted for publication in Nature and is provided in this format here as a response to the exceptional public-health crisis. This accepted manuscript will continue through the processes of copy editing and formatting to publication of a finalized version of record on nature.com. Please note there may be errors present in this version, which may affect the content, and all legal disclaimers apply.

 

The recently emerged SARS-CoV-2 Omicron variant encodes 37 amino acid substitutions in the spike (S) protein, 15 of which are in the receptor-binding domain (RBD), thereby raising concerns about the effectiveness of available vaccines and antibody therapeutics. Here, we show that the Omicron RBD binds to human ACE2 with enhanced affinity, relative to the Wuhan-Hu-1 RBD, and binds to mouse ACE2. Marked reductions of plasma neutralizing activity were observed against Omicron compared to the ancestral pseudovirus for convalescent and vaccinated individuals, but this loss was less pronounced after a third vaccine dose. Most receptor-binding motif (RBM)-directed monoclonal antibodies (mAbs) lost in vitro neutralizing activity against Omicron, with only 3 out of 29 mAbs retaining unaltered potency, including the ACE2-mimicking S2K146 mAb1. Furthermore, a fraction of broadly neutralizing sarbecovirus mAbs neutralized Omicron through recognition of antigenic sites outside the RBM, including sotrovimab2, S2X2593 and S2H974. The magnitude of Omicron-mediated immune evasion marks a major SARS-CoV-2 antigenic shift. Broadly neutralizing mAbs recognizing RBD epitopes conserved among SARS-CoV-2 variants and other sarbecoviruses may prove key to controlling the ongoing pandemic and future zoonotic spillovers.

 

doi: https://doi.org/10.1038/d41586-021-03825-4

 

https://www.nature.com/articles/d41586-021-03825-4

Anonymous ID: d69d70 Dec. 29, 2021, 7:52 a.m. No.15272465   🗄️.is 🔗kun   >>2528

Larry The Cable Guy

Lol.. RT @LloydLegalist:And the Academy Award, for greatest death scene of all time, goes to…

Kekkity really

https://t.co/xE9YO2Rszv

https://twitter.com/GitRDoneLarry/status/1475621580374003719?s=20

Anonymous ID: d69d70 Dec. 29, 2021, 7:58 a.m. No.15272508   🗄️.is 🔗kun   >>2519 >>2884

A political purge

 

https://twitter.com/MZHemingway/status/1476202749780008962?s=20

 

Marines say they're being 'crushed' over vaccine refusal: 'A political purge'

Zero religious exemptions for the COVID-19 vaccine have been granted to date, Marine Corps spokesman says

 

EXCLUSIVE: U.S. Marines are being "crushed" by President Biden’s COVID-19 vaccine mandate as thousands face dismissal for their continued refusal to get the shot, several active-duty Marines told Fox News Digital.

 

To date, 169 Marines have been discharged for refusing the vaccine, and thousands more face the same fate after the Department of Defense’s mandate on all active-duty service members went into effect for the Marine Corps on Nov. 28.

 

Marines are allowed to apply for a religious exemption, but so far not a single application regarding the COVID-19 vaccine, or any vaccine for that matter, has been approved, a Marine Corps spokesman told Fox News.

Several Marines who refuse to get the shot were granted anonymity by Fox News Digital, so they could speak freely. They said they are witnessing a "political purge" by the Biden administration that is forcing out the military’s "best and brightest" over deeply held beliefs they say are protected by the First Amendment.

 

"There’s something fundamentally wrong at this point with our nation’s leadership," said a major with more than 17 years of active service. "We are facing an unconstitutional edict that I think is very targeted as a political purge, taking out some of the best and brightest soldiers, sailors, airmen, Marines and guardians from the Space Force."

 

A lieutenant colonel with more than 19 years of active service said it appears that the military, specifically the Marine Corps, is discharging service members "as fast as they can and as brutally as they can, damaging every Marine as much as they can on the way out."

 

"The one message I got from the colonel above me was: ‘Tread very carefully, this is political, you will be crushed like an ant.’ And he told me that because he cares about me," the lieutenant colonel said. "Do I want to continue serving in an institution that crushes people for bringing up reasonable points in defending their faith?"

 

One master sergeant said it seems that "the louder I speak the tighter the screws are turned against me."

 

"When you’re expected to behave a certain way and to obey certain rules and follow certain processes, and then to see on the other end that that’s not a two-way street, that’s a violation of my morals that I can’t stand by and not speak out about," the master sergeant said.

 

The Marines who spoke with Fox News said they were on the receiving end of a "blanket" denial of religious exemptions, with their applications being rejected without consideration. Eight separate letters of denial provided to Fox News were nearly identical, citing "military readiness" as the primary reason for rejection.

 

"I saw one package from a sergeant who had attached, like, 30 pages of material to substantiate why his belief was sincere, under no lawful obligation to do so," the master sergeant said. "And then to have this as a response with no individual inquiry and just a generalized assertion of governmental interest is insulting."

 

"On the religious side, this is absolutely a travesty what’s happening," one chief warrant officer said. "People are getting blanket denials, they’re not addressing the individual concerns or beliefs of Marines who are submitting for religious accommodations, and I think that’s just horribly wrong. I honestly believe that they’re not really reading the packages."…

 

https://www.foxnews.com/politics/marines-being-crushed-vaccine-refusal-political-purge