Jim made a big move last night. Harbinger of things to come. Godspeed new BO and BV's!
Ionophore dig con't
https://en.wikipedia.org/wiki/Ionophore
see picrel
loads of zn+ ionophores
Ag+ ionophore looks tres interessant…
https://en.wikipedia.org/wiki/Streptomyces_virginiae
Streptomyces virginiae is a bacterium species from the genus of Streptomyces which has been isolated from soil.[1][3][4] Streptomyces virginiae produces actithiazic acid, virginiamycins and cycloserine.[4][5][6][7] Streptomyces virginiae also produces monensin A, monensin B, monensin C, monensin D, actithiazic acid.[4][8][9][10][11][12][13]
monensin
https://en.wikipedia.org/wiki/Monensin
Monensin is a polyether antibiotic isolated from Streptomyces cinnamonensis.[1]It is widely used in ruminant animal feeds.
<hmm kinda like ivermectin
The structure of monensin was first described by Agtarap et al. in 1967, and was the first polyether antibiotic to have its structure elucidated in this way. The first total synthesis of monensin was reported in 1979 by Kishi et al.[3]
Monensin A is an ionophorerelated to the crown ethers with a preference to form complexes with monovalent cations such as: Li+, Na+, K+, Rb+, Ag+, and Tl+.[4][5] Monensin A is able to transport these cations across lipid membranes of cells in an electroneutral (i.e. non-depolarizing) exchange, playing an important role as an Na+/H+ antiporter. Recent studies have shown that monensin may transport sodium ion through the membrane in both electrogenic and electroneutral manner.[6] This approach explains ionophoric ability and in consequence antibacterial properties of not only parental monensin, but also its derivatives that do not possess carboxylic groups. It blocks intracellular protein transport, and exhibits antibiotic, antimalarial, and other biological activities.[7] Theantibacterial propertiesof monensin and its derivatives are a result of their ability to transport metal cations through cellular and subcellular membranes.[8]
Uses[edit]
Monensin is used extensively in the beef and dairy industries to prevent coccidiosis, increase the production of propionic acid and prevent bloat.[9] Furthermore, monensin, but also its derivatives monensin methyl ester (MME), and particularly monensin decyl ester (MDE) are widely used in ion-selective electrodes.[10][11][12]
In laboratory research, monensin is used extensively to block Golgi transport.[13][14][15]
Toxicity[edit]
Monensin has some degree of activity on mammalian cells and thus toxicity is common. This is especially pronounced in horses, where monensin has a median lethal dose 1/100th that of ruminants.Accidental poisoning of equines with monensin is a well-documented occurrence which has resulted in deaths.
be careful with it
the FDA hates it which is usually a good sign
http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.836.9059&rep=rep1&type=pdf
gee they saw it cure colorectal cancer in humans in 2014
no wonder they hate it
The Wnt signaling pathway is required during embryonic development and for the maintenance of homeostasis in adult tissues. However, aberrant activation of the pathway is implicated in a number of human disorders, including cancer of the gastrointestinal tract, breast, liver, melanoma, and hematologic malignancies. In this study, we identified monensin, a polyether ionophore antibiotic, as a potent inhibitor of Wnt signaling.
don't ya love it when we cure cancer yet again and all before lunch
war morningshift!
it ionophoresgold
needs more ionophore