I'm still waking up. I'll find the actual study later. Childhood traumatic experience, both chronic or acute, hyperactivity the amygdala (fight or flight area of the brain) and causes atrophy of the neural connections to the prefrontal cortex (which usually helps mediate panic response).
Circumcision causes this kind of damage to children.
https://news.northeastern.edu/2020/02/20/childhood-trauma-changes-your-brain-but-it-doesnt-have-to-be-permanent/