Whoopi Goldberg?
https://www.dailymail.co.uk/sciencetech/article-10444111/Mysterious-object-4-000-light-years-Earth-releases-giant-burst-energy-three-times-hour.html
no idea
>Catherine Herridge
a succinct info-graphic
https://phys.org/news/2022-01-fossils-life-sars-cov-spike-syncytin-.html
There are no env, pol, gag, or pro genes defined as such for the SARS-CoV-2 genome, as is the case for the retroviruses, which must integrate into our DNA as part of their lifecycle. Curiously, researchers have found that the SARS-CoV-2 spike protein, behaving of its own accord, directly participates in the activation of endogenous retroviruses in our cells which contributes to observed pathology. What exactly is going on here?
>There are no env, pol, gag, or pro genes defined as such for the SARS-CoV-2 genome, as is the case for the retroviruses, which must integrate into our DNA as part of their lifecycle. Curiously, researchers have found that the SARS-CoV-2 spike protein, behaving of its own accord, directly participates in the activation of endogenous retroviruses in our cells which contributes to observed pathology. What exactly is going on here?
Fortunately, researchers found that there is virtually no direct sequence homology between spike and syncytin-1, and little chance of cross reactivity. Writing in the journal Animal Cells and Systems, Korean researchers tested a large panel of monoclonal antibodies and were able to conclude that while ancient genomic relics like HERVs can be activated in various tissues by SARS-CoV-2, there is no risk of cross reactivity or even infertility.
https://medicalxpress.com/news/2021-04-anti-parasitic-drug-lung-cell-fusion.html
Anti-parasitic drug may protect against lung cell fusion induced by SARS-CoV-2
A drug that is commonly used to treat tapeworm infections might help to prevent the formation of atypical fused cells in the lungs of patients with COVID-19, according to laboratory experiments reported this week in Nature.
Niclosamide was originally developed in the 1950s as a molluscicide against snails. It was later approved for use against tapeworm infections in humans, and is already known to be active against various viruses, including SARS-CoV-2.
Mauro Giacca and colleagues studied post-mortem samples from the lungs of 41 patients who had died from COVID-19 between March and May 2020, and found that the tissue often contains lung epithelial cells that have become fused together. Some of these fused cells, known as syncytia, contain over 20 different nuclei. The authors found that this fusion process is mediated by the spike protein of SARS-CoV-2, which triggers calcium oscillations and the activation of a protein called TMEM16F.
On the basis of these observations, the authors screened over 3,000 clinically approved drugs to look for molecules that block this spike-driven fusion of cells. The screen identified 83 drugs, and further experiments focused on 43 molecules that also protected against viral replication and cell damage. Of these, one of the most effective molecules was the anti-parasitic drug niclosamide. This drug was found to inhibit viral replication, blunt calcium oscillation in spike-expressing cells, suppress the activity of TMEM16F and prevent the formation of spike-induced syncytia in laboratory tests. The authors note that other drugs that are known to inhibit members of the TMEM16 family of proteins also performed well in their tests and could warrant further investigation as treatments for COVID-19.
https://www.tandfonline.com/doi/full/10.1080/19768354.2021.2019109
Syncytin, envelope protein of human endogenous retrovirus (HERV): no longer ‘fossil’ in human geome
Human endogenous retroviruses (HERVs) are ‘fossil viruses’ that resulted from stable integrations of exogenous retroviruses throughout evolution. HERVs are defective and do not produce infectious viral particles. However, some HERVs retain a limited coding capacity and produce retroviral transcripts and proteins, which function in human developmental process and various pathologies, including many cancers and neurological diseases. Recently, it has been reported that HERVs are differently expressed in COVID-19 disease caused by infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this review, we discuss the molecular structure and function of HERV ENV proteins, particularly syncytins, and their conventional roles in human development and diseases, and potential involvement in COVID-19 regarding the newly reported mental symptoms. We also address COVID-19 vaccine-related infertility concerns arising from the similarity of syncytin with the spike protein of SARS-CoV-2, which have been proved invalid.
HERVs have been participating in human evolution. Human development requires HERV ENV proteins to build a highly elaborate placenta. When dysregulated, those proteins unbalance cellular activities to aggravate human diseases such as cancers and mental illnesses. Recent studies indicate that the essential HERV ENV proteins may be involved in developing the psychotic and cognitive symptoms of COVID-19 disease. Based on clear scientific evidence, the speculation regarding COVID-19 vaccinations causing infertility due to a misunderstanding of viral protein structure has been proved wrong. HERV activities in COVID-19 disease strongly suggest that the ancient relics in the human genome play a significant role in human evolution even in the unprecedented pandemic of COVID-19.
You do you bro, who's this we you're talking about?
the royal wee demands
https://www.dailymail.co.uk/news/article-10445007/Prince-Andrew-files-legal-papers-DENYING-Virginia-Robertss-sex-abuse-allegations.html
Prince Andrew's defiant 41-denial response to Virginia Roberts' sex abuse lawsuit puts him on a 'collision course with the Palace' as he demands a JURY trial and says Ghislaine Maxwell was NOT his 'close friend'
Disgraced royal files legal papers denying all of Virginia Roberts allegations
The documents submitted today contain 41 denials of claims raised by Roberts
Prince Andrew says he 'lacks sufficient information to admit or deny' 40 claims
The Duke of York's legal team requested he be granted a trial by jury in the US
The Royal also claimed Ghislaine Maxwell was not a 'close friend' in legal papers
It comes after Andrew's motion to have the case thrown out was denied in Jan
Prince Andrew himself may well be forced to take the stand in New York this year