Anonymous ID: 0925ad March 1, 2022, 6:48 p.m. No.15759046   🗄️.is 🔗kun

Ivermectin: an award-winning drug with expected antiviral activity against COVID-19

Fabio Rocha Formiga,a,b,⁎ Roger Leblanc,c Juliana de Souza Rebouças,d Leonardo Paiva Farias,e Ronaldo Nascimento de Oliveira,f and Lindomar Penag

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Abstract

 

Ivermectin is an FDA-approved broad-spectrum antiparasitic agent with demonstrated antiviral activity against a number of DNA and RNA viruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Despite this promise, the antiviral activity of ivermectin has not been consistently proven in vivo. While ivermectin's activity against SARS-CoV-2 is currently under investigation in patients, insufficient emphasis has been placed on formulation challenges. Here, we discuss challenges surrounding the use of ivermectin in the context of coronavirus disease-19 (COVID-19) and how novel formulations employing micro- and nanotechnologies may address these concerns.