==Acceptable Science breakthrough–
For more than 20 years, his team and others around the world had been chasing an elusive quarry—the 3D structure of a crucial signaling protein in cells. In late 2021, his electron microscope images of the molecule started to come into focus. On December 8, postdoc Naotaka Tsutsumi and graduate student Caleb Glassman sent him an email with a startlingly clear picture of the protein latched on to a key receptor. "I was sitting in a meeting, and I realized we had it," recalls Garcia, a Howard Hughes Medical Institute Investigator at Stanford University. "I immediately left the meeting and ran back to the lab."
https://phys.org/news/2022-03-years-scientists-full-length-janus-kinase.html