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>Recently, NIH-funded researchers discovered a new class of antibiotics, called malacidins, by analyzing the DNA of the bacteria living in more than 2,000 soil samples, including many sent by citizen scientists living all across the United States [1]. While more work is needed before malacidins can be tried in humans, the compounds successfully killed several types of multidrug-resistant bacteria in laboratory tests. Most impressive was the ability of malacadins to wipe out methicillin-resistant Staphylococcus aureus (MRSA) skin infections in rats. Often referred to as a “super bug,” MRSA threatens the lives of tens of thousands of Americans each year [2].
>It might seem strange that soil would be the place to look for the most promising new antibiotics. But bacterial species in soil have been locked in a continuous antibiotic arms race with one another for millennia. When it comes to the chemistry needed to produce highly effective antibiotics, they are the experts.
https://directorsblog.nih.gov/2018/02/20/powerful-antibiotics-found-in-dirt/