As we move into middle age the body begins to produce less of some essential ingredients. S-Adenosylmethionine (SAMe) is one of these. SAMe is present in every cell in the body and participates in may essential processes. Too little of it causes anxiety and a feeling of impending doom. SAMe is sold in every health food store. I've been taking it for 25 years or more. If I stop the bad feelings return. While it is true that realization is beyond thought and emotion it is also true that emotion is physiological. Research SAMe and try it.