Afternoon anons…
Researchfag here..was asked to provide data to a major university that is assembling an endocannabinoid class..wrote all this up to send to the principal researcher (OUR guy)…thought some might find it of interest..sorry for the slip if deemed that way..enjoy the info!
"Awesome! As you dig and have question regarding systems, etc please ask..my library is extensive and somewhat categorized…I WANT very badly to teach YOU this system! If you have industry questions regarding the cannabis industry let me know as I can bring in industry experts on extraction, growing, etc when/if needed…
Ran across this: https://grants.nih.gov/grants/guide/pa-files/PA-18-465.html
There is no one lab that really specializes in doing endocannabinoid research. Folks like Dr. Ethan Russo (https://search.nih.gov/search?utf8=✓&affiliate=nih&query=ethan+russo) have studied cannabis (and now turpenes) and how it effect the endocannabinoid system (and also cross action in TRP channel). You will have to dig through research to assemble your thoughts and opinions.
I have structured my digs more around functions and flavonoids as I had already convinced myself of the efficacy of the endocannabinoid=ECS (you will get VERY tired of typing that word BTW..). Here are some summary papers that I think will help….
This paper, although a bit dated now, should be required reading: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2241751/
More current: https://www.nature.com/articles/ijo2015179
I know you know alot about the gut..I cannot read the full paper but I am sure you can: https://www.ncbi.nlm.nih.gov/pubmed/27413788
Care and feeding of the endocannabinoid system: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951193/
As mentioned, O3/O6 appears to me to be the way we naturally feed this system:
https://www.sciencedaily.com/releases/2017/07/170718142909.htm
https://www.medicalnewstoday.com/articles/318528.php
And if O3/O6 not in proper ratios…
https://www.ncbi.nlm.nih.gov/pubmed/12442909 ←- Dr. Simopolous would be a GREAT resource!
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808858/
https://www.nature.com/articles/nn.2736
As to ancestor..tis old and ancient…
https://www.ncbi.nlm.nih.gov/pubmed/16599912
When looking at how to influence…I will identify a flavonoid of interest (or turpene or alkaloid) and just search NIH.GOV for studies that combine endocannabinoid and the flavonoid. Then I pair with other effectors and access. GRAS herbs will synergize quit well under our system..but you have to use the ECS template.
An interesting paper on cancers (http://www.mdpi.com/1422-0067/17/2/230/htm). When you inflame, cells signal they are under control of the inflammatory by over-expressing an endocannabinoid called 2-AG. Basically a big "leave me alone..I am being repaired"…that is EXACTLY what cancer cells do as well. This appears to be fixable with a hard CB1 nueroreceptor hit/reset and can be caused by THC, but also from cyan (and I am sure other things) in nature. Some info on apricots seeds, do have some efficacy for cancer, probably because of the cyan…https://www.theverge.com/2017/9/11/16288104/apricot-kernels-cancer-cyanide-poisoning-case-study
We could be busy for the rest of our lives here just defining the elephant!"