Anonymous ID: 802732 July 6, 2022, 9:29 a.m. No.16643587   🗄️.is 🔗kun

>>16482986

 

Viruses. 2019 Aug 11;11(8):739. doi: 10.3390/v11080739.

 

Antibiotic Minocycline Prevents Respiratory Syncytial Virus Infection

 

Swapnil S Bawage 1 , Pooja M Tiwari 1 , Shreekumar Pillai 1 , Vida A Dennis 1 , Shree R Singh 2

 

PMID: 31405261 PMCID: PMC6723987 DOI: 10.3390/v11080739

 

Abstract

 

Treatment drugs, besides their specific activity, often have multiple effects on the body. The undesired effect of the drug may be repurposed as therapeutics, saving significant investigative time and effort. Minocycline has anti-cancer, anti-oxidant, anti-inflammatory, and anti-apoptotic properties. Presently, minocycline is also known to show anti-viral activity against Influenza virus, Japanese encephalitis virus, Simian immunodeficiency virus, Human immunodeficiency virus and West Nile virus. Here, we investigate the effect of minocycline on Respiratory syncytial virus (RSV), a common respiratory virus that causes severe mortality and morbidity in infants, children, and older adult populations. Currently, there is no effective vaccine or treatment for RSV infection; hence, there is a critical need for alternative and effective drug choices. Our study shows that minocycline reduces the RSV-mediated cytopathic effect and prevents RSV infection. This is the first study demonstrating the anti-viral activity of minocycline against RSV.

 

Keywords: Parkin-Ubiquitin pathway; RSV; antibiotics; antiviral; bronchiolitis; minocycline; neurodegenerative diseases; pneumonia; respiratory diseases.

 

https://pubmed.ncbi.nlm.nih.gov/31405261/