CDC Warns of a Bacteria that Causes Rare and Serious Disease Discovered in U.S. for 1st time in Environmental Samples
For the first time, a strain of bacteria generally seen in tropical and subtropical regions has been identified in the US, prompting a warning from the Centers for Disease Control and Prevention (CDC).
In a statement released on Wednesday, CDC announced it has identified for the first time in environmental samples in the US the bacteria that cause melioidosis or also called Whitmore’s disease, a rare and severe disease.
According to the press release, the CDC found out that two people who lived close to the Gulf Coast got sick with meliodosis, one in 2020 and the other in 2022 “prompting state health officials and CDC to take samples and test household products, soil, and water in and around both patients’ homes, with permission.”
“The bacteria, Burkholderia pseudomallei or B. pseudomallei, was identified through sampling of soil and water in the Gulf Coast region of Mississippi,” CDC said in a statement.
https://www.thegatewaypundit.com/2022/07/cdc-warns-bacteria-causes-rare-serious-disease-discovered-u-s-1st-time-environmental-samples/
Hijacking of the Host’s Immune Surveillance Radars by Burkholderia pseudomallei
Published online 2021 Aug 11.
Abstract
Burkholderia pseudomallei (B. pseudomallei) causes melioidosis, a potentially fatal disease for which no licensed vaccine is available thus far. The host-pathogen interactions in B. pseudomallei infection largely remain the tip of the iceberg. The pathological manifestations are protean ranging from acute to chronic involving one or more visceral organs leading to septic shock, especially in individuals with underlying conditions similar to COVID-19. Pathogenesis is attributed to the intracellular ability of the bacterium to ‘step into’ the host cell’s cytoplasm from the endocytotic vacuole, where it appears to polymerize actin filaments to spread across cells in the closer vicinity. B. pseudomallei effectively evades the host’s surveillance armory to remain latent for prolonged duration also causing relapses despite antimicrobial therapy. Therefore, eradication of intracellular B. pseudomallei is highly dependent on robust cellular immune responses. However, it remains ambiguous why certain individuals in endemic areas experience asymptomatic seroconversion, whereas others succumb to sepsis-associated sequelae. Here, we propose key insights on how the host’s surveillance radars get commandeered by B. pseudomallei.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8384953/
But check it out: Repurposed Chloroquine + Doxycycline
Potential of repurposing chloroquine as an adjunct therapy for melioidosis based on a murine model of Burkholderia pseudomallei infection
Trop Biomed. 2020 Jun 1;37(2):303-317.
Taken together the bacteriostatic action of doxycycline coupled with the cytokine-modulating effect of chloroquine gave full protection to B. pseudomallei-infected mice and involved inhibition of GSK3β. Findings from the present study using B. pseudomallei-infected BALB/c mice suggest that chloroquine is a plausible candidate for repurposing as adjunct therapy to treat acute B. pseudomallei infection.
https://pubmed.ncbi.nlm.nih.gov/33612800/
From 2021
What a coincidence
Vaccine research for deadly ‘Vietnam time bomb’ gets $3M grant
Melioidosis is one of the most misdiagnosed and deadliest diseases in the world, with a wide range of symptoms that can be mistaken for staph infections or diseases such as tuberculosis. University of Hawaiʻi at Mānoa School of Life Sciences researchers, led by Professor Tung Hoang, were awarded a $3-million contract from the Defense Threat Reduction Agency in the U.S. Department of Defense to create a vaccine to protect against melioidosis.
The disease has a 50% mortality rate and is listed by the Centers for Disease Control and Prevention (CDC) as a Tier 1 select agent, a list that also includes anthrax and Ebola, because the biological agents and toxins in this category “present the greatest risk of deliberate misuse with significant potential for mass casualties or devastating effect to the economy, critical infrastructure, or public confidence, and pose a severe threat to public health and safety,” according to the CDC.
“The threat to the military and civilian population is real in case of bioterrorism and biowarfare events,” Hoang said. “We also send our servicemen and women into harm’s way stationed in endemic countries where they could be exposed to the bacterium and the disease. Of course, they need protection. Likewise with travelers, traveling to endemic countries.”
https://www.hawaii.edu/news/2021/06/27/vaccine-research-vietnam-time-bomb/
saw this on /pol/
The most horrible part of all of it is that we're cursed with permanent sanity.