https://onlinelibrary.wiley.com/doi/10.1111/andr.13209
https://archive.ph/fE8a8
Covid-19 vaccination BNT162b2 temporarily impairs semen concentration and total motile count among semen donors
Background
The development of covid-19 vaccinations represents a notable scientific achievement. Nevertheless, concerns have been raised regarding their possible detrimental impact on male fertility
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Results
Repetitive measurements revealed −15.4% sperm concentration decrease on T2 (CI -25.5%–3.9%, p = 0.01) leading to total motile count 22.1% reduction (CI -35% - -6.6%, p = 0.007) compared to T0. Similarly, analysis of first semen sample only and samples' mean per donor resulted in concentration and TMC reductions on T2 compared to T0 - median decline of 12 million/ml and 31 million motile spermatozoa, respectively (p = 0.02 and 0.002 respectively) on first sample evaluation and median decline of 9.5×106 and 27.3 million motile spermatozoa (p = 0.004 and 0.003, respectively) on samples' mean examination. T3 evaluation demonstrated overall recovery. Semen volume and sperm motility were not impaired.
Discussion
This longitudinal study focused on SD demonstrates selective temporary sperm concentration and TMC deterioration three months after vaccination followed by later recovery verified by diverse statistical analyses.
Conclusions
Systemic immune response after BNT162b2 vaccine is a reasonable cause for transient semen concentration and TMC decline. Long-term prognosis remains good.