Here's the time-lapse leading up to the missile…
https://video.twimg.com/ext_tw_video/1006681031569625088/pu/vid/1280x720/xSJMeIQNUAAwYJ2N.mp4?tag=3
Photos appear to be taken every ≈40s and were at a 20s exposure, so there's a dead space of about 20s between each frame… would explain why we don't see the trail from the ground.
Recommend downloading and going frame by frame at the end. There is nothing visible in the clouds before the "missile" streaks past.
Mapped it out and there's no way it was the airliner. Flight path from the Air Ambulance company does match; however, it's odd that we do not see the heli through any other breaks in the clouds in the moments leading up.