"Several studies have shown that low serum T concentrations are associated with increased cardiovascular risk and mortality.7,8 It is not clear whether there is a causative relationship or an indirect association between T concentration and cardiovascular function.

Testosterone replacement therapy (TRT) has been shown to alleviate myocardial ischemia in men with coronary artery disease;9,10,11 increase exercise capacity in men with heart failure;12,13,14 and improve serum glucose levels, hemoglobin A1c (HbA1c) levels, and insulin resistance in men with diabetes and prediabetes.15,16 On the other hand, TRT has been linked to prostate cancer, polycythemia, and obstructive sleep apnea, and its long-term effects are unknown.17"

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8269837/

Testosterone, cardiomyopathies, and heart failure: a narrative review

https://mobile.twitter.com/joshg99/status/1560954134966243330

Josh Guetzkow 🐭

@joshg99

Major truth bombs to be dropped on the

@IsraelMOH

on Neil Oliver's show tonight on GB News. Starts 8pm Israel time, 6pm London time, 1pm Eastern. Not to be missed.

@thecoastguy

>>17422980

>>17422980

https://rumble.com/v1grkyj-ministry-of-health-caught-manipulating-results-of-study-on-covid-19-adverse.html

Aussie 3 _ 1 _ 13

@Aussie3_1_13

The panic sets in. Who is this video for? Australians or his Lockstep handlers?

Maybe for the MSM shills?

Funny looking room to put to film this video?

Brett you played the game and lost.

@AnnastaciaMP

are you next?

youtube.com

Brett Sutton starts his save my soul/backpeddling campaign

https://mobile.twitter.com/Aussie3_1_13/status/1560588685606731776

>>17422983

Brett Sutton starts his save my soul/backpeddling campaign

https://mobile.twitter.com/aapsonline/status/1560763402091626496

AssocAmerPhys&Surg

@AAPSonline

"Our results support a modest and transient [re]activation of HIV expression following SARS-CoV-2 mRNA vaccination … [T]here is no reason to think that this effect is clinically detrimental."

nature.com

SARS CoV-2 mRNA vaccination exposes latent HIV to Nef-specific CD8+ T-cells

Nature Communications - Here, the authors show in a cohort of people with HIV, COVID mRNA vaccination is followed by a transient boost in a particular profile of HIV-specific T-cell responses and a…

SARS CoV-2 mRNA vaccination exposes latent HIV to Nef-specific CD8+ T-cells

https://www.nature.com/articles/s41467-022-32376-z

S2 subunit of SARS-nCoV-2 interacts with tumor suppressor protein p53 and BRCA: an in silico study

https://pubmed.ncbi.nlm.nih.gov/32619819/

Abstract

Novel coronavirus disease 2019 (COVID-19) is the biggest threat to human being globally. The first case was identified in a patient with flu symptoms along with severe acute respiratory syndrome in Wuhan, China in December 2019 and now it has spread in more than 200 countries. COVID-19 is more lethal in the elderly and people with an underlying condition such as asthma, cancer, diabetes. Here we performed bioinformatic analysis to investigate the interaction of S2 subunit protein of SARS-nCoV-2 of novel coronavirus with tumor suppressor proteins p53 and BRCA-1/2. In this short communication we report the interaction between S2 subunit proteins with tumor suppressor proteins for the first time. This preliminary result will open up a new direction to investigate the effect of a novel coronavirus in cancer patients.

Lockdown fanatics can’t escape blame for this scandal

https://www.telegraph.co.uk/news/2022/08/19/lockdown-fanatics-cant-escape-blame-scandal/

Hysterectomies for children? CANCER.

Ovarian conservation = decreased all cause mortality

Ovarian Conservation and Overall Survival in Young Women With Early-Stage Cervical Cancer

https://pubmed.ncbi.nlm.nih.gov/27926642/

Abstract

Objective: To identify predictors of ovarian conservation at hysterectomy and to examine the association of ovarian conservation and survival of young women with early-stage cervical cancer.

Methods: This is a retrospective cohort study using the Surveillance, Epidemiology, and End Results Program to identify hysterectomy-based surgically treated patients with stage I cervical cancer diagnosed between 1983 and 2012 (N=16,511). Multivariable models were used to identify independent factors associated with ovarian conservation. Among the subgroup of 9,419 women younger than 50 years of age with stage I disease, survival outcomes and causes of death were examined for 3,908 (41.5%) women who underwent ovarian conservation at hysterectomy without radiotherapy.

Results: On multivariable analysis, age younger than 50 years, stage IA disease, and squamous histology were independent factors associated with ovarian conservation (all, P<.001). Among 5,526 women younger than 50 years of age with stage IA disease who underwent hysterectomy without radiotherapy, overall survival was significantly higher in patients undergoing ovarian conservation than in those undergoing oophorectomy (20-year rate, 93.5% compared with 86.8%, P<.001); cervical cancer-specific survival was similar between the patients who underwent ovarian conservation and those who underwent oophorectomy (98.8% compared with 97.8%, P=.12). On multivariable analysis, ovarian conservation remained an independent prognostic factor for improved overall survival (adjusted hazard ratio 0.63, 95% confidence interval [CI] 0.49-0.82, P=.001) and was independently associated with lower cumulative risks of death resulting from cardiovascular disease (20-year cumulative rate, 1.2% compared with 3.3%, adjusted hazard ratio 0.47, 95% CI 0.26-0.86, P=.014) and other chronic disease (0.5% compared with 1.4%, adjusted hazard ratio 0.24, 95% CI 0.09-0.65, P=.005) compared with oophorectomy. Both cervical cancer-specific survival (20-year rate, 93.1% compared with 92.0%, P=.37) and overall survival (86.7% compared with 84.6%, P=.12) were similar between ovarian conservation and oophorectomy among 3,893 women younger than 50 years of age with stage IB disease who underwent hysterectomy without radiotherapy.

Conclusion: Among young women with stage IA cervical cancer, ovarian conservation at hysterectomy is associated with decreased all-cause mortality including death resulting from cardiovascular disease and other chronic diseases.

>>17423008

"In no analysis or age group was oophorectomy associated with increased survival."

Ovarian conservation at the time of hysterectomy and long-term health outcomes in the nurses' health study

https://pubmed.ncbi.nlm.nih.gov/19384117/

Abstract

Objective: To report long-term health outcomes and mortality after oophorectomy or ovarian conservation.

Methods: We conducted a prospective, observational study of 29,380 women participants of the Nurses' Health Study who had a hysterectomy for benign disease; 16,345 (55.6%) had hysterectomy with bilateral oophorectomy, and 13,035 (44.4%) had hysterectomy with ovarian conservation. We evaluated incident events or death due to coronary heart disease (CHD), stroke, breast cancer, ovarian cancer, lung cancer, colorectal cancer, total cancers, hip fracture, pulmonary embolus, and death from all causes.

Results: Over 24 years of follow-up, for women with hysterectomy and bilateral oophorectomy compared with ovarian conservation, the multivariable hazard ratios (HRs) were 1.12 (95% confidence interval [CI] 1.03-1.21) for total mortality, 1.17 (95% CI 1.02-1.35) for fatal plus nonfatal CHD, and 1.14 (95% CI 0.98-1.33) for stroke. Although the risks of breast (HR 0.75, 95% CI 0.68-0.84), ovarian (HR 0.04, 95% CI 0.01-0.09, number needed to treat=220), and total cancers (HR 0.90, 95% CI 0.84-0.96) decreased after oophorectomy, lung cancer incidence (HR=1.26, 95% CI 1.02-1.56, number needed to harm=190), and total cancer mortality (HR=1.17, 95% CI 1.04-1.32) increased. For those never having used estrogen therapy, bilateral oophorectomy before age 50 years was associated with an increased risk of all-cause mortality, CHD, and stroke. With an approximate 35-year life span after surgery, one additional death would be expected for every nine oophorectomies performed.

Conclusion: Compared with ovarian conservation, bilateral oophorectomy at the time of hysterectomy for benign disease is associated with a decreased risk of breast and ovarian cancer but an increased risk of all-cause mortality, fatal and nonfatal coronary heart disease, and lung cancer. In no analysis or age group was oophorectomy associated with increased survival.

>>17423014

>>17423008

"Elective BSO should be discouraged in women under 50 years old. In postmenopausal women, however, BSO can reduce ovarian cancer rates without an adverse impact on CHD, sexual dysfunction, hip fractures, or cognitive function."

A critical evaluation of the evidence for ovarian conservation versus removal at the time of hysterectomy for benign disease

https://pubmed.ncbi.nlm.nih.gov/23865788/

Abstract

Background: Women undergoing hysterectomy for benign disease are presented with the choice of ovarian conservation or removal. The beneficial effect on ovarian cancer must be weighed against the risks of ovarian hormone withdrawal. Wide variations in practice patterns exist.

Methods: The purpose of this review article is to summarize and critically evaluate the existing primary evidence regarding the impact of adnexal conservation versus removal on the specific health issues of ovarian cancer, coronary heart disease (CHD), sexual and cognitive function, and osteoporotic hip fractures.

Results: Elective bilateral salpingo-oophorectomy (BSO) in women under 50 years is associated with an increased risk of CHD and sexual dysfunction. In women older than 50 years, there is no observed association between BSO and CHD, sexual dysfunction, osteoporotic hip fractures, or cognitive function. Oophorectomy is associated with a lower risk of death from ovarian cancer.

Conclusion: Elective BSO should be discouraged in women under 50 years old. In postmenopausal women, however, BSO can reduce ovarian cancer rates without an adverse impact on CHD, sexual dysfunction, hip fractures, or cognitive function.

"The findings on CVD lend some support to the position that elective bilateral oophorectomy (surgical menopause) at hysterectomy for benign diseases should be discouraged based on an increased risk of CVD."

Type of menopause, age of menopause and variations in the risk of incident cardiovascular disease: pooled analysis of individual data from 10 international studies

https://pubmed.ncbi.nlm.nih.gov/32563191/

Abstract

Study question: How does the risk of cardiovascular disease (CVD) vary with type and age of menopause?

Summary answer: Earlier surgical menopause (e.g. <45 years) poses additional increased risk of incident CVD events, compared to women with natural menopause at the same age, and HRT use reduced the risk of CVD in women with early surgical menopause.

>>17423020

Younger menopause = increase in CVD

Age at natural menopause and risk of incident cardiovascular disease: a pooled analysis of individual patient data

https://pubmed.ncbi.nlm.nih.gov/31588031/

Abstract

Background: Early menopause is linked to an increased risk of cardiovascular disease mortality; however, the association between early menopause and incidence and timing of cardiovascular disease is unclear. We aimed to assess the associations between age at natural menopause and incidence and timing of cardiovascular disease.

Interpretation: Compared with women who had menopause at age 50-51 years, women with premature and early menopause had a substantially increased risk of a non-fatal cardiovascular disease event before the age of 60 years, but not after age 70 years. Women with earlier menopause need close monitoring in clinical practice, and age at menopause might also be considered as an important factor in risk stratification of cardiovascular disease for women.

>>17423028

wrong img…

Testosterone replacement therapy and cardiovascular risk

https://www.nature.com/articles/s41569-019-0211-4

Abstract

Testosterone is the main male sex hormone and is essential for the maintenance of male secondary sexual characteristics and fertility. Androgen deficiency in young men owing to organic disease of the hypothalamus, pituitary gland or testes has been treated with testosterone replacement for decades without reports of increased cardiovascular events. In the past decade, the number of testosterone prescriptions issued for middle-aged or older men with either age-related or obesity-related decline in serum testosterone levels has increased exponentially even though these conditions are not approved indications for testosterone therapy. Some retrospective studies and randomized trials have suggested that testosterone replacement therapy increases the risk of cardiovascular disease, which has led the FDA to release a warning statement about the potential cardiovascular risks of testosterone replacement therapy. However, no trials of testosterone replacement therapy published to date were designed or adequately powered to assess cardiovascular events; therefore, the cardiovascular safety of this therapy remains unclear. In this Review, we provide an overview of epidemiological data on the association between serum levels of endogenous testosterone and cardiovascular disease, prescription database studies on the risk of cardiovascular disease in men receiving testosterone therapy, randomized trials and meta-analyses evaluating testosterone replacement therapy and its association with cardiovascular events and mechanistic studies on the effects of testosterone on the cardiovascular system. Our aim is to help clinicians to make informed decisions when considering testosterone replacement therapy in their patients.

Role of sex hormones in modulating myocardial perfusion and coronary flow reserve

https://link.springer.com/article/10.1007/s00259-022-05675-2

Abstract

Background

A growing body of evidence highlights sex differences in the diagnostic accuracy of cardiovascular imaging modalities. Nonetheless, the role of sex hormones in modulating myocardial perfusion and coronary flow reserve (CFR) is currently unclear. The aim of our study was to assess the impact of female and male sex hormones on myocardial perfusion and CFR.

Conclusion

Our experimental data in mice indicate that sex differences in myocardial perfusion are primarily driven by testosterone. Given the diagnostic importance of PET-MPI in clinical routine, further studies are warranted to determine whether testosterone levels affect the interpretation of myocardial perfusion findings in patients.

Abnormal Levels of Sex Hormones Are Associated with Cardiovascular Disease

Sex hormone levels are tightly regulated through various mechanisms and are crucial for optimal health. Abnormal sex hormone levels (e.g., too high or too low) can cause a myriad of disruptive responses like specific comorbidities and increased risks for diseases

https://link.springer.com/article/10.1007/s11897-022-00555-0

Evaluation of the Interaction of Sex Hormones and Cardiovascular Function and Health

Estrogen is likely neuroprotective

Perspective: Estrogen and the Risk of Cognitive Decline: A Missing Choline(rgic) Link?

https://pubmed.ncbi.nlm.nih.gov/34849527/

Abstract

Factors that influence the risk of neurocognitive decline and Alzheimer's disease (AD) may provide insight into therapies for both disease treatment and prevention. While age is the most striking risk factor for AD, it is notable that the prevalence of AD is higher in women, representing two-thirds of cases. To explore potential underlying biological underpinnings of this observation, the intent of this article is to explore the interplay between cognitive aging and sex hormones, the cholinergic system, and novel hypotheses related to the essential nutrient, choline. Mechanistic evidence points toward estrogen's neuroprotective effects being strongly dependent on its interactions with the cholinergic system, a modulator of attentional functioning, learning, and memory. Estrogen has been shown to attenuate anticholinergic-induced impairments in verbal memory and normalize patterns of frontal and occipital cortex activation, resulting in a more "young adult" phenotype. However, similar to estrogen replacement's effect in cardiovascular diseases, its putative protective effects may be restricted to early postmenopausal women only, supportive of the "critical window hypothesis." Estrogen's impact on the cholinergic system may act both locally in the brain but also through peripheral tissues. Estrogen is critical for inducing endogenous choline synthesis via the phosphatidylethanolamine N-methyltransferase (PEMT) pathway of phosphatidylcholine (PC) synthesis. PEMT is dramatically induced in response to estrogen, producing not only a PC molecule and source of choline for the brain but also a key source of the long-chain omega-3 fatty acid, DHA. Herein, we highlight novel hypotheses related to hormone replacement therapy and nutrient metabolism aimed at directing future preclinical and clinical investigation.

In men: "Low endogenous levels of testosterone may be related to reduced cognitive ability, and testosterone…"

In men: "Low endogenous levels of testosterone may be related to reduced cognitive ability, and testosterone

https://pubmed.ncbi.nlm.nih.gov/17132744/

Abstract

Background: Testosterone levels decline as men age, as does cognitive function. Whether there is more than a temporal relationship between testosterone and cognitive function is unclear. Chemical castration studies in men with prostate cancer suggest that low serum testosterone may be associated with cognitive dysfunction. Low testosterone levels have also been observed in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI). This paper reviews the current clinical evidence of the relationship between serum testosterone levels and cognitive function in older men.

Methods: A systematic literature search was conducted using PubMed and EMBASE to identify clinical studies and relevant reviews that evaluated cognitive function and endogenous testosterone levels or the effects of testosterone substitution in older men.

Results: Low levels of endogenous testosterone in healthy older men may be associated with poor performance on at least some cognitive tests. The results of randomized, placebo-controlled studies have been mixed, but generally indicate that testosterone substitution may have moderate positive effects on selective cognitive domains (e.g. spatial ability) in older men with and without hypogonadism. Similar results have been found in studies in patients with existing AD or MCI.

Conclusions: Low endogenous levels of testosterone may be related to reduced cognitive ability, and testosterone substitution may improve some aspects of cognitive ability. Measurement of serum testosterone should be considered in older men with cognitive dysfunction. For men with both cognitive impairment and low testosterone, testosterone substitution may be considered. Large, long-term studies evaluating the effects of testosterone substitution on cognitive function in older men are warranted.

>>17423064

>In men:

"Basic studies have shown that androgens have neuroprotective effects and that androgen deficiency impairs cognitive function by increasing oxidative stress and decreasing synaptic plasticity, among other effects. Additionally, clinical studies have also shown that androgen deficiency is closely related to cognitive impairment"

An Updated Review: Androgens and Cognitive Impairment in Older Men

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691320/

Abstract

Androgens are some of the most important sex hormones in men, and they maintain important physiological activities in the human body. Cognitive impairment is one of the most common manifestations of aging in the elderly population and an important factor affecting the quality of life of elderly individuals. The levels of sex hormones in elderly people decrease with age, and low levels of androgens in older male individuals have been closely linked to the development of cognitive impairment. Basic studies have shown that androgens have neuroprotective effects and that androgen deficiency impairs cognitive function by increasing oxidative stress and decreasing synaptic plasticity, among other effects. Additionally, clinical studies have also shown that androgen deficiency is closely related to cognitive impairment. This article reviews the relationship between low androgen levels and cognitive impairment, their potential mechanisms, and the effects of testosterone supplementation in improving cognition.

Conclusions

With aging, declines in cognitive function are one of the important factors affecting the quality of life of elderly individuals. Most clinical studies have confirmed that there is a close relationship between low androgen levels and cognitive impairment in elderly individuals; meanwhile, basic research has shown that testosterone contributes to the maintenance of cognitive function, which is further supported by corresponding mechanistic research. Androgen supplementation seems to be a promising treatment for improving cognitive impairment in older men. However, most of the existing clinical studies about androgen supplementation do not support that androgen supplementation can be helpful for cognitive improvement in older men (69–72). Together, androgen deficiency is an important cause of cognitive impairment in older men and should receive attention. More studies of testosterone supplementation in improving cognition are needed.

>>17422974

>>17423008

>>17423075

>>17423064

>>17423051

>>17423059

>>17423046

>>17423037

>>17423033

>>17423028

>>17423020

>>17423016

>>17423014

These studies illustrate the FACT thatthey are KNOWINGLY shortening lives through 'gender reassignment surgeries' and hormone treatments to children and adults, which result inincreased CVD/Cardiovascular disease, CANCER, and rapid onset cognitive decline.

ON PURPOSE.

>>17423079

Joe Rogan slams The Vatican as a 'country filled with pedophiles and stolen art' and criticizes Popes for 'covering up' molestation scandals

Podcaster Joe Rogan calls The Vatican City a 'country filled with pedophiles' during a conversation about the history of scandals in the Catholic Church

'It's a hundred acre rather, country inside of a city filled with pedophiles,' Rogan said on the Wednesday airing of his podcast, The Joe Rogan Experience

Rogan was joined with fellow podcasters Francis Foster and Konstantin Kisin

The trio discussed how previous Pope's have hid molesting Priest rather than excommunicating them from the church

https://www.dailymail.co.uk/news/article-11059093/Joe-Rogan-slams-Vatican-country-filled-pedophiles-stolen-art.html

Joe Rogan slammed the Catholic church in a Wednesday podcast episode where he calls The Vatican as a 'country filled with pedophiles and stolen art.'

Rogan sat alongside fellow podcasters - Francis Foster and Konstantin Kisin - during an episode of The Joe Rogan Experience to discuss the Catholic Pope Francis and the various covered up scandals.

'Even the outrage about things you should be outraged about, like Jeffery Epstein, that outrage was balanced. Right? Sort of. Right? But what about the Catholic church?' Rogan asked.

'Like why isn’t everybody really freaking out about - I was just in Italy and one of the things that’s nuts is the Vatican is a country. It’s a country filled with pedophiles. It’s a country filled with pedophiles and stolen art. It’s a small, like hundred yard - like what is it? A hundred acres, I think. Yeah. It’s a hundred acre rather, country inside of a city filled with pedophiles.'

'Yeah, absolutely,' Foster said

Kisin interrupted, 'This is why I love American, man. Cause in the UK, we have libel laws. So if you say something like that and you then have to be able to prove it, otherwise you can get sued.'

'You can kind of prove that,' Rogan responded.

Foster added, 'I read the other day that, I think it was five, six years ago, the age of consent in the Vatican City was 12-years-old.'

'I hope that's not true,' Kisin said as Producer Jamie Vernon was queued to fact check Foster's claim.

'Oh my God. It's true,' Rogan said as he proceeded to read off a Google search result. Oh my God. The Vatican city’s equal age of consent being raised from 12 to 18, following the announcement of an overall the Catholic church criminal code by Pope Francis'

Rogan added, 'Francis is like the most progressive guy, right? In terms of Popes.'

Forster responded, 'I mean, that's not really saying a lot. Do you know what I mean?

The trio were referencing Pope Francis who has been reigning in the Vatican since 2013. The pope repealed the former Vatican City law, written in 1889, that said the age of consent was 12-years-old before it changed to 18-years-old about a decade ago, according to the Atlantic.

pt1

>>17423167

Rogan continued, 'The Benedict guy, he was wanted in other countries for crimes against humanity. I mean like what he was doing was really evil. He was moving offenders to other places and one of them he moved a guy that went on to molest a hundred deaf kids!'

'It's insanity. I mean this guy was already molesting and then they say well let's just - instead of trying him and removing him from the church - we'll just move him to a place where people can't hear.'

'It's amazing how people can just cover this stuff up,' Kisin added.

Rogan's comments on the Catholic Church come as the church proceeds to battle with sex abuse and cover-up scandals that has aired across the globe.

Earlier this year, former Pope Benedict XVI, 95, expressed 'shock and shame' at child abuse carried out in his diocese in the 1980s after a report found he knowingly failed to take action against the priests involved.

Benedict served in the dioceses of Munich and Freising in Germany from 1977 to 1982 and denied responsibility in the cases of abuse.

Some of the cases say Benedict allegedly failed to act and remove clergymen who committed sexual abuse acts.

Benedict - whose civilian name is Josef Ratzinger - became the first pope to step down from the role in 600 years in 2013. He now lives a secluded life in a former convent inside the grounds of the Vatican.

Abuse scandals continue to come to light, as a study commissioned by the German Bishops' Conference in 2018 concluded that 1,670 clergymen in the country had committed some form of sexual attack against 3,677 minors between 1946 and 2014.

In 2019, it was revealed that a secret Catholic group operating out of a small Michigan town had reportedly served as a 'rapid-response' team to protect hundreds of priests accused of sexual abuse.

Opus Bono Sacerdotii, a non-profit, would reportedly work out of a series of unmarked buildings in rural Michigan. The non-profit would provide money, shelter, transport, legal help and other support to many Catholic priests accused of sexual abuse across the country.

Stripped of their collars and cassocks, they went unnoticed in the small town of Dryden as they were escorted into a dingy warehouse across from an elementary school playground, the Associated Press reported at the time.

When a serial pedophile was sent to jail for abusing dozens of minors, Opus Bono was there for him, with regular visits and commissary cash.

When a priest admitted sexually assaulting boys under 14, Opus Bono raised funds for his defense.

When another priest was criminally charged with abusing a teen, Opus Bono later made him a legal adviser.

At the time, leaders of the church denied having any official relationship with the group.

In May, a church in New Mexico was subjected to pay a settlement agreement of $121.5 million to settle a bankruptcy case caused by sex abuse scandals. The scandals involved 375 victims against 74 priests in the state.

https://twitter.com/nailainayat/status/1561009916596338688

Naila Inayat

@nailainayat

Another day, another child thrown to the wolves. 12-year-old Christian girl Zarvia Pervaiz abducted, converted to Islam, married to 40 yr old abductor Imran in Rawalpindi. He has 3 children and a wife who helped him abduct Zarvia. Court rules the minor girl to stay with abductor.