>Flu hospitalizations at highest level in a decade, health officials say
Many were concerned about anti-body dependent enhancement (ADE) when the COVID vaccines were released:
"The simple definition of ADE is "raising antibodies that don't protect, but actually make a viral infection even worse". And obviously, that's the opposite of what you want."
https://www.science.org/content/blog-post/antibody-dependent-enhancement
Rush To Produce, Sell Vaccine Put Kids In Philippines At Risk
May 3, 20192:53 PM ET
The vaccine, called Dengvaxia, is aimed at helping children in Puerto Rico and other U.S. territories where dengue is a problem.
But this vaccine has a dark — and deadly — history. One that has led to criminal charges in the Philippines, sparked national panic and fueled a massive measles outbreak that has already killed more than 355 people.
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But in the end, estimates are that more than 100,000 Philippine children received a vaccine that health officials say increased their risk of a severe and sometimes deadly condition.
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For some children, the vaccine didn't seem to work. In fact, Halstead says, it appeared to be harmful. When those kids caught dengue after being vaccinated, the vaccine appeared to worsen the disease in some instances. Specifically, for children who had never been exposed to dengue, the vaccine seemed to increase the risk of a deadly complication called plasma leakage syndrome, in which blood vessels start to leak the yellow fluid of the blood.
https://www.npr.org/sections/goatsandsoda/2019/05/03/719037789/botched-vaccine-launch-has-deadly-repercussions
"Here's the problem. For children who have already been exposed to dengue, the vaccine is safe and works pretty well. But there is an unusual thing about the dengue virus. The second infection can be a lot worse than the first. So for kids who have never had the disease, the vaccine acts as the first exposure. So if they are exposed to dengue later on, they're at a higher chance of having this severe reaction."
https://www.npr.org/2019/05/02/719366831/dengue-vaccine-controversy-in-the-philippines