>>17830780

Tyb

>There is a war for your DNA.

>Protect your DNA.

WEF

PRECISION MEDICINE

5 things to know about CRISPR and gene editing in the COVID era

Aug 12, 2020

1. CRISPR is the search engine for biology.

The advent of CRISPR-based diagnostics fundamentally means a better understanding of the molecular world around us – for areas ranging from human disease to crop health.

Infectious disease is a key use-case area for the diagnostic applications of CRISPR. It’s become clear that one of its most powerful uses is its ability to provide reliable molecular information quickly and in a variety of formats.

International borders, workplaces, homes and maybe even concerts, conferences or other large events could benefit greatly from having tests for COVID-19 (and other diseases) that give gold-standard results within minutes. During a pandemic, this type of information is critical for fully reopening economies and engaging in robust contact tracing.

“We created a robust test for the novel coronavirus within weeks – particularly important as we contemplate the fact that it is a matter of when, not if, we must combat future pandemics beyond the current one,” says Trevor Martin.

Beyond these more immediate uses, there is exciting potential for testing our environment more broadly, through monitoring samples from sewage or air. These measurements could give us unprecedented insight into our ecosystems and how they influence our health.

https://www.weforum.org/agenda/2020/08/crispr-gene-testing-editing-covid19-coronavirus-diagnostics-precision-medicine-healthcare/

>>17830932

0B 0B 0

A Royal disease with a royal price tag

The Royals have not just passed great rulers down the bloodline but also a rare condition that prevents clotting of blood.

The disease was traced to Queen Victoria who was the first recorded carrier of the disease.

Hemophilia or the Royal Disease Hemophilia is an inherited bleeding disorder in which the blood does not clot properly.

Regulators have approved the world's most expensive medicine that costs $3.5 million per patient

US regulators have approved a hemophilia drug that will cost $3.5 million per patient, making it the world's most expensive medicine.

The Food and Drug Administration (FDA) announced on Tuesday that it had approved Hemgenix, the first gene therapy to treat adults with hemophilia B, a genetic bleeding disorder resulting from missing or insufficient levels of blood-clotting Factor IX.

The FDA said the condition affected one in 40,000 people, mostly men. It accounts for about 15% of all hemophilia cases.

In a study Hemgenix, distributed by CSL Behring, cut the number of bleeding events expected over a year by 54%. It also removed the need for 94% of patients to receive infusions of Factor IX, saving them considerable time and money.

https://www.businessinsider.com/fda-approves-worlds-most-expensive-drug-costing-35-million-patient-2022-11

>>17831333

Trips chkd

Manmade DNA Möbius strip

Chemical origami used to create a DNA Möbius strip

By carefully selecting DNA sequences, researchers produced self-assembling …

DIANA GITIG - 10/18/2010, 12:29 PM

Researchers at Arizona State University have recently used origami to fold DNA into a Möbius strip. Why? Because its frickin' cool, that’s why. The scientists, who hail from the departments of biophysics, chemistry, and biochemistry, chose to make one out of DNA "not only because it is artistically inspiring, but also because it will likely display unique material properties that may be applied to create novel molecular devices."

A Möbius strip is a surface with only one side and only one boundary. To create one, they used single stranded M13mp 18 viral DNA as a scaffolding, and added 164 short pieces of DNA as staple strands attached to the scaffolding to help fold it into the desired structure. Each strip is roughly 210nM long, contains 61.5 helical turns, and is about 25-30nM wide, containing eleven DNA double helices and the gaps between them. There are 10.67 base pairs per helical turn. This very closely mimics the 10.5 pairs in B-type DNA, the form most commonly found in cells. They found an almost equal distribution of left- and right-handed chiralities in their strips, and concluded that the handedness is determined randomly. (DNA in biological systems is left-handed).

https://arstechnica.com/science/2010/10/chemical-origami-used-to-create-a-dna-mobius-strip/

>>17831431

The Cops and Courts have been taking DNA samples for a while now.

Police Can Now Take Your DNA After Any Arrest

The Supreme Court has ruled that police can take DNA samples from anybody under arrest for any crimes, regardless of whether DNA is relevant to their arrest

Rose Eveleth Contributor June 4, 2013

https://www.smithsonianmag.com/smart-news/police-can-now-take-your-dna-after-any-arrest-91140837/