Anonymous ID: 7e5528 Nov. 29, 2022, 6:42 p.m. No.17851871   🗄️.is 🔗kun   >>1969 >>2050 >>2058

nucleotide excision repair (NER).

(Figure 3):

detection of damage;

excision of the section of DNA that includes and surrounds the error;

filling in of the resulting gap by DNA

 

In eukaryotes, this complex process relies on the products of approximately 30 genes. Defects in some of these genes have been shown to cause the human disease XP, as well as other conditions that share a risk of skin cancer that is elevated about a thousandfold over normal. More specifically, eukaryotic NER is carried out by at least 18 protein complexes via four discrete steps

polymerase;

and sealing of the nick between the newly synthesized and older DNA (Figure 4).

 

In bacteria (which are prokaryotes), however, the process of NER is completed by only three proteins, named UvrA, UvrB, and UvrC.

>https://www.nature.com/scitable/topicpage/dna-damage-repair-mechanisms-for-maintaining-dna-344/#