"as the world turns"
"nothing can stop what is coming"
"watch the water"
etc…
Is this work attracting the micronova? Are the precursors to the micronova gifting us to do this?
As above so bellow/ within without.
All bodies are worlds, and all worlds are bodies.
o7
if you want to optimize survival odds, Florida should be in your rearview. By A LOT
for prepping to be a vigilante pirate instead of prepping your own food, water, meds, etc perhaps?
MicroRNA miR-21, Cancer and Circadian Rhythm Related Cardiovascular Accidents
https://doorlesscarp953.substack.com/p/microrna-mir-21-cancer-and-circadian
Circadian rhythms
Various pathologies are associated with a disrupted circadian rhythm. This paper explores the signalling and hormonal pathways. Note the importance of BMAL1 expression for regulating circadian rhythms:
Circadian rhythms in immunity (2020)
Abstract
Purpose of review
This review is focused on the existing evidence for circadian control of innate and adaptive immune responses to provide a framework for evaluating the contributions of diurnal rhythms to control of infections and pathogenesis of disease.
Recent findings
Circadian rhythms driven by cell-autonomous biological clocks are central to innate and adaptive immune responses against microbial pathogens. Research during the past few years has uncovered circadian circuits governing leukocyte migration between tissues, the magnitude of mucosal inflammation, the types of cytokines produced, and the severity of immune diseases. Other studies revealed how disruption of the circadian clock impairs immune function or how microbial products alter clock machinery.
Summary
Revelations concerning the widespread impact of the circadian clock on immunity and homeostasis highlight how the timing of inflammatory challenges can dictate pathological outcomes and how the timing of therapeutic interventions likely determines clinical efficacy. An improved understanding of circadian circuits controlling immune function will facilitate advances in circadian immunotherapy.
Conclusion
This work demonstrates that daily mechanical stimulation can act as a timing cue that is sufficient to entrain the peripheral circadian clock in vitro. This discovery may be exploited to induce and sustain circadian physiology within into predictive in vitro model systems, including OOAC systems. Integration of the circadian clock within these systems will enhance their potential to accurately recapitulate human diurnal physiology and hence augment their predictive value as drug testing platforms and as realistic models of human (patho)physiology.
microRNA are the real regulators of gene transcription.
https://denutrients.substack.com/p/microrna-are-the-real-regulators
https://mobile.twitter.com/StatChrisCotton/status/1598398931381223440
Christine Cotton OFFICIEL
@StatChrisCotton
Summary of my conclusions on the Pfizer's clinical trial
Full report with methodological argumentation here
https://christine-cotton.1ere-page.fr/wp-content/uploads/2022/03/ENG-Vaccine-expertise-GCP-CCotton-2022-02-14-v2_AC.pdf
@IamBrookJackson
@joshg99
@DrEliDavid
@TheJikky
@ClareCraigPath
@hedleyrees
@DrAseemMalhotra
Proximal Orchestrations:
Newly released emails cast more doubt than ever on the official story of Covid-19 as a naturally occurring virus.
(Article by Nicholas Wade)
Emails Cast More Doubt on the Official Covid Story | City Journal
Newly released messages discuss how to discredit the idea that the virus escaped from a lab.
https://www.city-journal.org/emails-cast-more-doubt-on-the-official-covid-story#.Y40wqUVYdm8.twitter
"The emails begin with vigorous statements by the American virologists explaining their initial view that the virus had indeed been concocted in a laboratory."
"Mike Farzan of Scripps said that he was 'bothered by the furin site' and had 'a hard time explaining that as an event outside the lab.'"
"The same point worried Bob Garry, a virologist at Tulane University. 'I really can’t think of a plausible natural scenario…where you insert exactly 4 amino acids 12 nucleotides…I just can’t figure out how this gets accomplished in nature,' he wrote."
"Kristian Andersen of Scripps..tells Fauci that..'some of the features (potentially) look engineered.' He..and his three colleagues, Holmes, Farzan, and Garry, 'all find the genome inconsistent with expectations from evolutionary theory,' meaning it wasn’t made in nature."
"This would be a stunning discovery, if true, and one that its authors doubtless intended to publish as soon as possible..Andersen surely expected praise for this sensational insight and that Fauci would give helpful advice about presenting the discovery to the public."
"But would the NIH leadership indeed have been overjoyed to see..public inquiries into the possibility of a link between its support of research at Wuhan and the outbreak of the pandemic? Quick action would be needed to avert any such disaster."
"Instead of appreciation, Andersen finds himself the very next day on a teleconference with Fauci, Collins, and senior British medical officials, being confronted by a bunch of European gain-of-function virologists baying for his blood."
"To Andersen’s dismay,..Fauci is not..pleased. Collins, too, is seriously unhappy, fretting in an email the next day that 'the voices of conspiracy will quickly dominate, doing great potential harm to science and international harmony.'"
"Evidently, Andersen has gotten the wrong answer. Right scientifically, maybe, but oh, so erroneous politically."
"Fauci, Collins, and Farrar..control a huge chunk of the money available for virology research. What serious prospects could there be for Andersen’s..career if he should persist, despite heavy hints, in doing 'great potential harm to science and international harmony?'"
"They felt they had found something really important and their funding agency would be proud of it too, but on the teleconference they learned the opposite. They felt Fauci would really want to know, but it’s the last thing he wanted to know."
"They were so concerned they had damaged their fundability that the only way they could retrieve it was to suborn science on behalf of their paymaster"
"The Proximal Origins paper was the recantation of the dangerous conclusion they had outlined in their January 31st email." Only when this palinode is..in press does Andersen receive the praise he had at first expected"
MAIDS in Canada from2017
https://www.cbc.ca/news/canada/manitoba/medically-assisted-death-could-save-millions-1.3947481
Across Canada, journal calculates up to $136.8 M in savings
New research suggests medically assisted dying could result in substantial savings across Canada's health-care system.
Doctor-assisted death could reduce annual health-care spending across the country by between $34.7 million and $136.8 million, according to a report published in the Canadian Medical Association Journal on Monday.
The savings exceedingly outweigh the estimated $1.5 to $14.8 million in direct costs associated with implementing medically assisted dying.
"The take-away point is that there may be some upfront costs associated with offering medical assisted dying to Canadians, but there may also be a reduction in spending elsewhere in the system and therefore offering medical assistance in dying to Canadians will not cost the health care system anything extra," said Aaron Trachtenberg, an author of the report and a resident in internal medicine at the University of Calgary.
Cost has to be a part of the discussion
The researchers used numbers from the Netherlands and Belgium, where medically assisted death is legal, combined with Canadian spending data from Ontario. Trachtenberg stressed that means the work is theoretical and needs to be readdressed when Canada starts collecting large scale data at home.
After June 17, 2016 when Bill C-14 became law, provinces began rolling out their plans to deal with requests for doctor-assisted death.
Manitoba has set up a Medical Assistance in Dying team (MAID). More than 100 patients have contacted MAID, with 24 receiving medically assisted deaths as of Jan. 6.
"In a resource-limited health care system, anytime we roll out a large intervention there has to be a certain amount of planning and preparation and cost has to be a part of that discussion," Trachtenberg said, adding the provinces' differing plans could impact the cost structure of implementation.
"It's just the reality of working in a system of finite resources."
The report estimated that about one to four per cent of Canadians will die using physician-assisted death. Of those, 50 per cent will be between the ages of 60 and 80.
The report estimates a 50-50 split between men and women.
About 80 per cent of patients will have cancer and 60 per cent will have their lives shortened by one month while 40 per cent will have their lives shortened by one week.
End-of-life care has high costs in Canada
Health-care costs increase substantially among patients nearing the end of their life, Trachtenberg said.
"Canadians die in hospitals more often than, say, our counterparts in America or Europe and … we have a lack of palliative care services even though we are trying to improve that. And therefore people end up spending their final days in the hospital," he said.
"Hospital-based care costs the health care system more than a comprehensive palliative care system where we could help people achieve their goal of dying at home."
The report used Manitoba as an example, where 20 per cent of health care costs are attributable to patients within the six months before they die, despite their representing only one per cent of the population. Patients who choose medical assistance in dying may forego this resource-intensive period, the report said.
"Whenever we roll out a large-scale intervention there has to be a discussion around costs. But we do not suggest that costs should ever be considered at an individual level," Trachtenberg said.
"We are not suggesting that patients or providers consider costs when making this very personal and intimate decision to request or provide medical assistance in dying."
The report also emphasized that it is only a cost analysis and doesn't include the clinical effects on patients. Patient-level research will need to be done before true economic evaluation of medical assistance in dying in terms of cost-effectiveness and utility can be done, the report said.
Medically assisted deaths could save millions in health care spending: Report