Both Harry Reid and Nancy Pelosi credit significant injuries (to Reid and Pelosi's husband, respectively) for causing them to [finally] give up Congressional leadership positions after decades each.

-PELOSI

Nancy Pelosi's daughter said her father's injuries from the alleged intruder's attack contributed to her mother's decision to step down from party leadership.

https://www.forbes.com/sites/carlieporterfield/2022/12/13/paul-pelosis-attack-led-to-nancy-pelosi-stepping-down-from-party-leadership-daughter-says/?sh=7877b66a230f

-REID

“It ended his career,” Wilkes said, noting that after 30 years in the Senate, Reid decided after undergoing surgeries for his injuries not to seek re-election. “It changed his life. It changed his wife’s life forever.”

https://apnews.com/article/768c129dfa2d454e89ee7dd6b01620b2