>>18054554

Gene ID: 12023, updated on 27-Sep-2022

Summary

Official Symbol

Barx2provided by MGI

Official Full Name

BarH-like homeobox 2provided by MGI

Primary source

MGI:MGI:109617

See related

Ensembl:ENSMUSG00000032033 AllianceGenome:MGI:109617

Gene type

protein coding

RefSeq status

VALIDATED

Organism

Mus musculus

Lineage

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus

Also known as

Barx2b; 2310006E12Rik

Summary

Enables DNA-binding transcription factor activity; chromatin binding activity; and sequence-specific DNA binding activity. Acts upstream of or within cartilage condensation; myotube differentiation; and regulation of transcription by RNA polymerase II. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; limb; sensory organ; and skin. Orthologous to human BARX2 (BARX homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]

Expression

Biased expression in duodenum adult (RPKM 37.2), small intestine adult (RPKM 29.3) and 6 other tissues See more

Orthologs

human all

https://www.ncbi.nlm.nih.gov/gene/12023

Product Specific Information

MA5-12023 targets Glial Fibrillary Acidic Protein in IF, IHC (P), and WB applications and shows reactivity with Chicken, Human, Porcine, and Rat samples.

The MA5-12023 immunogen is glial Fibrillary Acidic Protein.

MA5-12023 was successfully used to detect astrocytes in E18 Sparague Dawley primary cortical cells.

Target Information

GFAP (Glial fibrillary acidic protein) is a member of the class III intermediate filament protein family. GFAP is heavily and specifically expressed in astrocytes and certain astroglia of the central nervous system, in satellite cells of peripheral ganglia, and in non-myelinating Schwann cells of peripheral nerves. In addition, neural stem cells strongly express GFAP. Antibodies to GFAP are very useful as markers of astrocytic cells. In addition, many types of brain tumor, presumably derived from astrocytic cells, heavily express GFAP. GFAP is also found in the lens epithelium, Kupffer cells of the liver, in some cells in salivary tumors and has been reported in erythrocytes. GFAP is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing of the GFAP gene results in multiple transcript variants encoding distinct isoforms.

https://www.thermofisher.com/antibody/product/GFAP-Antibody-clone-ASTRO6-Monoclonal/MA5-12023