>>18064555
trips chek'd, Rude Awakening inbound.
Anand Ram
@TheMenta1ist
"FDA and vaccine makers were warned about induction of inappropriate IgE and IgG4 antibodies by COVID vaccines. They ignored it. Prediction comes true, with devastating consequences."
arumugham.substack.com
Long before EUA, FDA and vaccine makers were warned about induction of inappropriate IgE and IgG4…
These basic immunology concepts have been understood for years based on research into parasite infections, vaccine induced food allergies and autism.
"…Cardiomyocytes take up mRNA lipid nanoparticles & start making and displaying spike protein on their surface. IgG4 attaches to the spike protein, attracting eosinophils to destroy the heart muscle cells, mistaking them for a parasite. Eosinophilic myocarditis is the result."
"With new, mild, parasite infections, IgE dominates. As parasite load increases…the IgG4/eosinophil defense mechanism kicks in. When the body does not have sufficient time to switch from IgE to IgG4 mode…results in severe allergic reactions (anaphylaxis) which can kill."
"Cow’s milk protein contaminated vaccines cause the induction of IgG4 antibodies directed against the folate receptor alpha, a protein in cow’s milk. This causes 75% of autism cases."
1:21 AM · Jan 3, 2023
Class switch towards non-inflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination
Pascal Irrgang https://orcid.org/0000-0003-2829-6096, Juliane Gerling https://orcid.org/0000-0003-3528-7251, Katharina Kocher https://orcid.org/0000-0003-2331-3838, Dennis Lapuente https://orcid.org/0000-0002-9833-5313, Philipp Steininger, Katharina Habenicht, Monika Wytopil https://orcid.org/0000-0002-4919-9773, Stephanie Beileke, Simon Schäfer, […] , and Matthias Tenbusch https://orcid.org/0000-0003-3951-9056 +13 authors Authors Info & Affiliations
Science Immunology
22 Dec 2022
First Release
DOI: 10.1126/sciimmunol.ade2798
Abstract
RNA vaccines are efficient preventive measures to combat the SARS-CoV-2 pandemic. High levels of neutralizing SARS-CoV-2-antibodies are an important component of vaccine-induced immunity. Shortly after the initial two mRNA vaccine doses, the IgG response mainly consists of the pro-inflammatory subclasses IgG1 and IgG3. Here, we report that several months after the second vaccination, SARS-CoV-2-specific antibodies were increasingly composed of non-inflammatory IgG4, which were further boosted by a third mRNA vaccination and/or SARS-CoV-2 variant breakthrough infections. IgG4 antibodies among all spike-specific IgG antibodies rose on average from 0.04% shortly after the second vaccination to 19.27% late after the third vaccination. This induction of IgG4 antibodies was not observed after homologous or heterologous SARS-CoV-2 vaccination with adenoviral vectors. Single-cell sequencing and flow cytometry revealed substantial frequencies of IgG4-switched B cells within the spike-binding memory B-cell population (median 14.4%; interquartile range (IQR) 6.7–18.1%) compared to the overall memory B-cell repertoire (median 1.3%; IQR 0.9–2.2%) after three immunizations. Importantly, this class switch was associated with a reduced capacity of the spike-specific antibodies to mediate antibody-dependent cellular phagocytosis and complement deposition. Since Fc-mediated effector functions are critical for antiviral immunity, these findings may have consequences for the choice and timing of vaccination regimens using mRNA vaccines, including future booster immunizations against SARS-CoV-2.
https://www.science.org/doi/10.1126/sciimmunol.ade2798