Changes of ECG parameters after BNT162b2 vaccine in the senior high school students

https://pubmed.ncbi.nlm.nih.gov/36602621/

Abstract

The purpose of this study is to determine the ECG parameter change and the efficacy of ECG screening for cardiac adverse effect after the second dose of BNT162b2 vaccine in young population. In December 2021, in cooperation with the school vaccination system of Taipei City government, we performed a ECG screening study during the second dose of BNT162b2 vaccines. Serial comparisons of ECGs and questionnaire survey were performed before and after vaccine in four male-predominant senior high schools. Among 7934 eligible students, 4928 (62.1%) were included in the study. The male/female ratio was 4576/352. In total, 763 students (17.1%) had at least one cardiac symptom after the second vaccine dose, mostly chest pain and palpitations. The depolarization and repolarization parameters (QRS duration and QT interval) decreased significantly after the vaccine with increasing heart rate. Abnormal ECGs were obtained in 51 (1.0%) of the students, of which 1 was diagnosed with mild myocarditis and another 4 were judged to have significant arrhythmia. None of the patients needed to be admitted to hospital and all of these symptoms improved spontaneously. Using these five students as a positive outcome, the sensitivity and specificity of this screening method were 100% and 99.1%, respectively. Conclusion: Cardiac symptoms are common after the second dose of BNT162b2 vaccine, but the incidences of significant arrhythmias and myocarditis are only 0.1%. The serial ECG screening method has high sensitivity and specificity for significant cardiac adverse effect but cost effect needs further discussed. What is Known: • The incidence of cardiac adverse effects was reported to be as high as 1.5 per 10 000 persons after the second dose BNT162b2 COVID-19 vaccine in the young male population based on the reporting system. What is New: • Through this mass ECG screening study after the second dose of BNT162b2 vaccine we found: (1) The depolarization and repolarization parameters (QRS duration and QT interval) decreased significantly after the vaccine with increasing heart rate; (2) the incidence of post-vaccine myocarditis and significant arrhythmia are 0.02% and 0.08%; (3) The serial ECG screening method has high sensitivity and specificity for significant cardiac adverse effect.

Effects of the second dose of COVID-19 vaccines in patients with autoimmune rheumatic diseases with hybrid immunity

https://pubmed.ncbi.nlm.nih.gov/36583801/

Abstract

Patients with autoimmune rheumatic diseases with a previous infection by the SARS-CoV-2 virus have exaggerated responses to a single dose of COVID-19 vaccination as compared to fully vaccinated infection naive patients. The second dose is currently recommended at an extended gap after the infection, but the information available regarding response to the second dose in this subgroup is limited. Patients with AIRDs previously infected with COVID-19, who have received at least one dose of AZD1222/ChAdOx1 (n = 200) were included and stratified based on vaccine doses (V), and infection (I) into I + V, I + V + V, V + I, V + V + I. Anti-RBD (receptor binding domain) antibodies were compared across the four groups. In 49 patients of the I + V + V group (AZD12222), paired sera were compared for antibody levels and neutralization after each vaccine dose. Thirty patients with hybrid immunity after BBV152 and 25 with complete vaccination without infection were included as controls. The highest anti-RBD antibody levels were observed in the V + V + I group (18,219 ± 7702 IU/ml) with statistically similar titers in the I + V + V (10,392 ± 8514 IU/ml) and the I + V (8801 ± 8122 IU/ml). This was confirmed in the 49 paired samples that paradoxically showed a lowering of antibody titers after the second dose [9626 (IQR: 4575-18,785)-5781 (2484-11,906); p < 0.001]. Neutralization of the Delta variant was unaffected but Omicron neutralization was significantly reduced after the second dose [45.7 (5.3-86.53)-35% (7.3-70.9); p = 0.028]. Ancillary analyses showed that only the hybrid immune sera could neutralize the Omicron variant and AZD1222 hybrids performed better than BBV152 hybrids. The second dose of AZD1222 did not boost antibody titers in patients with RD who had COVID-19 previously. In the analysis of paired sera, the second dose led to a statistically significant reduction in antibody titers and also reduced neutralization of the Omicron variant.

TROPISM: Why The Spike Protein Can Turn Every Major Organ Into A Graft: Spike Entry Via ACE2 Should Have Struck Terror From The Start

A World Where No Organ Is Safe: We Must Keep The Spike Out Of Cells, This Is The Solution

https://wmcresearch.substack.com/p/tropism-why-the-spike-protein-can

Autopsies are a gold standard for information. The dead do tell us stories, and those stories can save our lives. Before we look at the story of an autopsy, let’s look at another story. The story of viruses and the cells they infect.

You may not know this, but there are many, many more viruses on this planet than there are stars in the universe. Yet, very, very few actually do us harm. Why? Because they DO NOT HAVE THE ABILITY TO INVADE OUR CELLS. In other words, they do not have a key to get in. To give you an idea:

An estimated 10 nonillion (10 to the 31st power) individual viruses exist on our planet—enough to assign one to every star in the universe 100 million times over.

These pathogens are extraordinarily picky about the cells they infect, and only an infinitesimally small fraction of the viruses that surround us actually pose any threat to humans.

There are more viruses than stars in the universe. Why do only some infect us?

https://www.nationalgeographic.com/science/article/factors-allow-viruses-infect-humans-coronavirus

So, HIV infects cells with CD4. CD4 is found on the surface of immune cells such as T helper cells, monocytes, macrophages, and dendritic cells. Herpes infects the following cells:

But the Spike Protein of SARS-CoV-2 infects cells with ACE2. This very simple observation is actually (at least to me) quite terrifying, yet everyone glossed it over, never a peep about this. Ever. Look at the TROPISM (cells that the Spike Protein can infect) compared to the viruses we just discussed.

Now. Why is this so disturbing? Because our cells have something called a Major Histocompatibility Complex on them. This presents parts of proteins that are ground up and then served up for the immune system to surveil. Think of it as Quality Control. The MHC molecule dishes up a few peptides from what’s inside the cell and the immune cells inspect it. If all the peptides displayed from the cell are YOU, all is quiet and the immune cells move on. If the peptides are NOT YOU, well, then that cell is, frankly, f*cked. It gets destroyed.

So, if we have Spike Protein entering VIRTUALLY EVERY CELL IN EVERY ORGAN, what do you suppose happens? You body views the cells as foreign. They are invaders, they must be destroyed. This is what happens in organ transplants. You need a good match, our immune systems are virtuosi. The best. If it sees something is not you, It will take it out.

This brings us to the story of our autopsy. A post vaccination autopsy was performed – and it found spike EVERYWHERE. Just as would be predicted.

First case of postmortem study in a patient vaccinated against SARS-CoV-2

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8051011/

So, I ask you. What do you think the immune system will do when it sees all these cells presenting foreign peptides? In every organ?

ENDOTHELIAL DESTRUCTION.

We have journeyed long and far together. Now we contemplate what we were initially told, and understand its significance. Clearly, the only way to protect ourselves, is to prevent the Spike Protein from entering our cells. If it cannot enter our cells, it cannot harm us. Just as the other nonillion viruses on the planet do not. Oh yeah, the stats. What are the odds that something naturally evolved to infect virtually every cell in our body? Interesting question, no?

Peter A. McCullough, MD, MPH™

@P_McCulloughMD

More ecological data suggesting SARS-CoV-2 infection did not increase rates of myocarditis. Agrees with Tuvali et al. Big surge we are seeing now is attributable to the C19 vaccines as warned by FDA. #courageousdiscourse

https://twitter.com/P_McCulloughMD/status/1612130690199339011

Lady Spaulding

@LadySpaulding11

The paper was sent to school newspaper editors at 20 schools that mandate bivalent boosters with an offer to introduce them to some of the authors for an interview. Not ONE of the student journalists responded, even though this issue impacts each one of their readers.

Quote Tweet

Jeff Childers, Esq.

@jchilders98

·

7h

BMJ's Journal of Med Ethics said between 31,207 and 42,836 young adults under 30 must be jabbed to prevent one single hospitalization, but 18.5 of them will be seriously injured by the shots.

They concluded, "University booster mandates are unethical[.]"

https://jme.bmj.com/content/early/2022/12/05/jme-2022-108449

https://mobile.twitter.com/LadySpaulding11/status/1612103863531720708

Bioscience Resource Project

@BioSRP

In her book 'Dark Winter'

@Globalbiosec

points to inconsistencies in the #Ebola2014 Guinea zoonosis narrative. But both observations are consistent with a #lableak in Sierra Leone:

p162: "we showed the #Ebola epidemic could be detected months before the WHO knew" and

p168, below:

https://mobile.twitter.com/BioSRP/status/1611122183987945472

Karolina Corin

@kccorin

·

Jan 4

We received 7 new batches of #FOIA documents from

@StateDept

in response to ongoing litigation.

@StateDept

redacted over 130 pages. Many seem to be related to Covid-19 and its origins.

Francisco de Asis

@franciscodeasis

·

Jan 4

Replying to

@kccorin

and

@StateDept

It seems we all did a good job in 2020 showing the inconsistencies of WIV

Rebecca

@Rebecca21951651

·

Jan 4

Replying to

@franciscodeasis

@kccorin

and

@StateDept

And sharp folks

@StateDept

knew of the conflicts of interest of Peter Deszak and

@EcoHealthNYC

: (page 68 of latest dump)

Francisco de Asis

@franciscodeasis

·

Jan 4

Replying to

@Rebecca21951651

@kccorin

and 2 others

EHA & GVP

Rebecca

@Rebecca21951651

·

Jan 4

Replying to

@franciscodeasis

@kccorin

and 2 others

.

@StateDept

officials pointed out Peter Deszak was "very conflicted and avowedly closed-minded"

page 12 "FL-2022-00076" FOIA dump by

@USRightToKnow

@garyruskin

@R_H_Ebright

@sciencecohen

@hholdenthorp

@jocelynkaiser

@fayeflam

@natashaloder

@amymaxmen

@zasdak

@Ayjchan

Rebecca

@Rebecca21951651

Replying to

@Rebecca21951651

@franciscodeasis

and 14 others

Wonder what

@PeterDaszak

of

@EcoHealthNYC

was doing at the US Embassy in China in May 2018?

Did his input go into the

@StateDept

cables outlining poor biosafety at the Wuhan Institute?

@joshrogin

@NateSilver538

@RandPaul

@HouseGOP

@NIHDirector

Quote Tweet

Francisco de Asis

@franciscodeasis

·

Jan 4

Replying to @Rebecca21951651 @kccorin and 2 others

EHA & GVP

https://mobile.twitter.com/Rebecca21951651/status/1610832703104118785

>>18105357

https://mobile.twitter.com/zasdak/status/1610704901142724609

Dr. Peter Zasdak 🦗 'ᵖᵃʳᵒᵈʸ'

@zasdak

From the latest batch of FOIA'd State department documents.

Dr. Peter Zasdak 🦗 'ᵖᵃʳᵒᵈʸ'

@zasdak

·

Jan 4

Replying to

@zasdak

▇▇▇▇▇▇

@state

.gov knows what's up.

https://mobile.twitter.com/Kevin_McKernan/status/1612132095031390208

Kevin McKernan

@Kevin_McKernan

·

5h

I see a lot MDs who bitch but can't graph. Many have taken up pitch forks against Peter over cherry picked critiques. Some fair points

It took me < 10 minutes to scrape the goodsciencin page and parse it for Age to gauge if

@P_McCulloughMD

was in the ball park or nuts.

Kevin McKernan

@Kevin_McKernan

·

5h

So 1075 patients are <=39. Not 1598 but also collected over 2 years not decades. So he is directionally correct.

Yes, the data should be further scrutinized for gunshot wounds over vaccines but be honest. You didn't require this scrutiny over COVID deaths.

Kevin McKernan

@Kevin_McKernan

·

5h

I can't find any critiques of the sloppy CDC COVID death metrics from the physicians attacking McCullough over his recent cohort selection. How many deaths are really from C19 versus with it?

Selective outrage farming.

https://mobile.twitter.com/AlecStapp/status/1611500829441138688

Alec Stapp

@AlecStapp

Data shows American teenagers becoming less independent & more risk averse over time

https://mobile.twitter.com/DrJohnB2/status/1612155129607618562

Dr John B.

@DrJohnB2

"Our data demonstrated that the Spike protein could induce long-term transcriptional suppression of mitochondria metabolic genes and cause cardiac fibrosis and myocardial contractile impairment …"

https://biorxiv.org/content/10.1101/2023.01.05.522853v1

#CovidVaccine

https://mobile.twitter.com/DrJohnB2/status/1612158753201086465

Dr John B.

@DrJohnB2

"Post-vaccination individuals with PASC-like symptoms exhibit markers of platelet activation & pro-inflammatory cytokine production which may be driven by the persistence of SARS-CoV-2 S1 protein persistence in intermediate & non-classical monocytes."

https://researchsquare.com/article/rs-1844677/v1?utm_source=substack&amp%3Butm_medium=email&utm_medium=email

https://mobile.twitter.com/DrJohnB2/status/1612152520834523136

Dr John B.

@DrJohnB2

The planned inclusion of SARS-CoV-2 nucleocapsid (N) protein in future COVID-19 vaccines & boosters: a bad idea. A new study shows that the N protein share homology with proteins associated with multiple sclerosis (MS)!

https://nature.com/articles/s41598-022-27348-8