Many of these vaccine research articles will preface everything with saying that vaccines are the best way and safe but this this this

pay attention to the 'but… this this this'

4.2. Influenza Vaccine

Multiple cases have linked influenza vaccinations to autoimmune complications in relation to the endocrine system. A case study demonstrated a 21-year-old Caucasian male patient who presented with adrenal crisis one week following the administration of the influenza vaccine alongside diphtheria, tetanus, and acellular pertussis (DTaP) [49]. In addition, Hsiao et al. reported a case involving a 25-year-old female who developed neck pain and swelling two days following influenza vaccine administration [50]. Fine needle aspiration of the lesion revealed multinuclear giant granulomas in the thyroid gland. Another case of a 36-year-old female demonstrated symptoms of tachycardia, anxiety, and tenderness in her neck one month following the administration of H1N1 influenza vaccine [51]. The patient was later diagnosed with subacute thyroiditis.

Furthermore, numerous studies have linked influenza vaccination to Guillain–Barré syndrome (GBS). For instance, in the 1970s during the influenza vaccination program among military personnel in the US, one case of GBS was described for every 10,000 vaccinated individuals [52]. Additionally, in a meta-analysis of 39 studies published between 1981 and 2014, an increased risk of GBS following the administration of influenza vaccine was found; this increase was particularly prominent in patients receiving H1N1 vaccination [53].

Vasculitis has also been linked to influenza vaccination in several studies. In an evaluation of 45 reports between 1966 to 2016, Watanbe found that 65 patients developed vasculitis in the aftermath of influenza vaccination [54]. Among the cases, 13 were large vessel vasculitis, 42 were small vessel vasculitis, and 5 were single organ vasculitis. Eight cases of giant cell arteritis (GCA) were also reported by Soriano et al. [55]. Moreover, Shoenfeld et al. reported 2 cases of ANCA-associated vasculitis following influenza vaccination [8]. The association was further elaborated in a study that displayed four cases of ANCA-associated vasculitis after influenza vaccinations, these cases included new onset as well as relapses [56].

Influenza vaccinations have also been associated with APS [47], narcolepsy [57], ADEM [46,58], Crohn’s disease [59], and transverse myelitis [60].

4.1. Hepatitis B Vaccine

Hepatitis B vaccine is considered to be the vaccine with most autoimmune manifestations among current vaccines. In an analysis of 93 individuals with a mean age of 26.5 years, Zafrir et al. [44] reported symptoms at a mean of 43.2 days following hepatitis B vaccinations. Of the sample, 70% of the participants had neuropsychiatric symptoms, 60% showcased neurological manifestations including photosensitivity 30%, paresthesia 23%, short term memory loss 15%, dizziness 14%, gait disturbance 8.6%, burning sensation 7.5%, paralysis 7.5%, optic neuritis 7.5%, cognitive dysfunction 7.5%, neurogenic bladder and bowel 6.5%, ataxia 6.5%, seizure 5%, nystagmus 4%, vertigo 4%, hyporeflexia 4%, Lhermitte’s phenomenon 3%, hyperesthesia 3%, urinary retention 2%, dysarthria 2%, tinnitus 2%, nuchal rigidity 1%, myoclonic jerks 1%, and tics 1%. Moreover, 32% of the patients also displayed ophthalmological manifestations; among these were eye field visual changes 20.4%, diplopia 6.5%, visual loss 6.4%, uveitis 3%, conjunctivitis 2%, gaze disturbance 2%, and retinopathy 1%. Musculoskeletal signs were demonstrated by 59% of the patients, these symptoms involved arthralgia 36.5%, myalgia 25.8%, joint stiffness 19.3%, back pain 14%, arthritis 10.7%, muscle spasm 7.5%, muscle tone 3%, and muscle wasting 3%. Nausea, vomiting, abdominal pain, weight loss, decreased appetite, diarrhea, and constipation were among the GI symptoms found in 50% of the patients. Skin-related side effects were registered in 30% of patients including rash, malar rash, photosensitivity, and Raynaud’s phenomenon. Finally, 60% of patients displayed general symptoms such fatigue 41.9%, weakness 20.4%, fever 18%, chills 7.5%, and lymph node enlargement 5%.

Certain studies have also reported cases of SLE [45], acute disseminated encephalomyelitis (ADEM) [46], and elevations in anti-phospholipid antibodies [47,48] following the administration of recombinant HBV vaccine.