Alex, I'll take Holy Moly for 100.
Why That Ohio Town Is Named “East Palestine”
Towns such as East Palestine, Ohio, were established by 19th-century religious Christian settlers; they chose those names to express their spiritual attachment to the land and people of the Bible.
…Elsewhere in Ohio, there are towns named Hebron, Gilboa, Canaan, and Shiloh (two of them, in fact). There’s even a Sodom, which was given its name after a prohibition advocate, disappointed at the small turnout for his lecture in 1840, jokingly compared the locale to that infamous biblical center of sin.
In Texas, in addition to Palestine, there are towns named Hebbronville and Joshua. There is a Hebron in North Dakota and a Sinai in South Dakota, a Jerusalem in Arkansas, a Jericho in Vermont, a Bethlehem as well as a Nazareth in Pennsylvania, and a Zion in Maryland. Nearly every state has one or more towns named after biblical sites or individuals. Altogether, there are more than 1,000 biblically-named towns from coast to coast.
Towns such as East Palestine, Ohio, were established by 19th-century religious Christian settlers; they chose those names to express their spiritual attachment to the land and people of the Bible. When they thought of Palestine, they recalled the Jewish kingdoms and temples of ancient times, as well as the events surrounding the origins of Christianity in the Jewish town of Bethlehem. In their prayers, they prayed for the return of the Jews to the Holy Land, which they understood to be inextricably linked to the coming messianic age.
https://jewishjournal.com/commentary/opinion/356310/why-that-ohio-town-is-named-east-palestine/