https://twitter.com/Parsifaler/status/1628207745001299979
Walter M Chesnut
@Parsifaler
This is very important. And terrifying. What the hell has been done to us?
Intercellular mRNA trafficking via membrane nanotube-like extensions in mammalian cells
A Stealth Weapon of Cellular Mass Destruction: The Spike Protein, its mRNA and Nanotubes
https://wmcresearch.substack.com/p/a-stealth-weapon-of-cellular-mass
A Stealth Weapon of Cellular Mass Destruction: The Spike Protein, its mRNA and Nanotubes
The mechanism by which the Spike may be inducing systemic errors of translation and why it is hidden
Tunneling nanotube bridge provides a conduit for SARS-COV-2 to cross from one cell to another. A closeup is shown below with viruses in transit. Credit: Anna Pepe/Institut Pasteur.
A paper in Scientific American caught my attention. In July of last year it was shown that SARS-CoV-2 travels incognito from cell to cell via nanotubes. I have kept this in the back of my mind. The recent discovery that the Spike remodels actin (see previous post on platelets and actin remodeling) brought this paper back to the front. The Spike caused the formation of filopodia. Actin remodeling also creates nanotubes, which are modified filopodia.
This mechanism also allows the Spike to propagate throughout the body COMPLETELY UNDETECTED AND ESCAPE THE IMMUNE RESPONSE.
The nanotube route “is a shortcut that propagates infection fast and between different organs, permissive or not permissive, to the infection,” says Chiara Zurzolo, a cell biologist at the Pasteur Institute, who conducted the study. “And it might be also a way for the virus to hide and escape the immune response.”
The virus may be capable of commandeering a cell’s own nanotubes, diverting them away from other routine tasks, such as transferring lipids and proteins between cells. Early research on SARS-CoV-2 suggested that it might be able to hijack similar cell projections. A 2020 paper published in the journal Cell found that cells infected with the novel coronavirus extended out antennalike feelers called filopodia with viral particles onboard.
By tagging viral proteins with antibodies and fluorescent compounds so that they stood out, the researchers captured high-resolution images of the virus within the tunneling nanotubes that connected the cells. They could see both viral particles and little sacs called vesicles in which the virus copies itself. They also detected proteins that are part of the cellular machinery the virus uses to replicate.
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