Press conference: House GOP border security package

Leader Scalise and Reps. Jordan, Green, McCaul unveil border security package

https://www.youtube.com/watch?v=fYQGpKt2XOc

Zineb Riboua

Congratulations to @hoffman_bruce Georgetown’s CJC for the

first Symposium on The Protocols of The Elders of Zion!

Panelists @Doranimated, @Ed_Husain, & @AmbDennisRoss emphasized how Gulf States and Israel are reshaping the Middle East, and how the Abraham Accords are participating in the revival of the land of tolerance.

12:45 PM · Apr 27, 2023

https://twitter.com/zriboua/status/1651628546287181830

>>18762582

>Congratulations to @hoffman_bruce

Bruce Hoffman has been studying terrorism & insurgency for 4+ decades and is a senior fellow at @CFR_org.

>Panelists @Doranimated,

Sits in a tank and thinks. (Followed by ECW)

>@Ed_Husain, &

Writer | Londoner by birth, Washingtonian by choice | Defender of Greco-Abrahamic civilisation and our allies

>@AmbDennisRoss

Former negotiator, Warriors, Niners, Giants, UCLA fan, and proud Saba of Dan, Michael, and Ben-Ben

No wonder they give him cheat sheets!

Biden struggles through CHILDREN's press conference

• as he tries to remember the last country he visited and the name of Top Gun (before a kid puts him out of his misery and tells him to go back inside)

▶ Biden fielded questions from kids on 'Take Your Child to Work Day'

▶ He fielded inquiries about his favorite color and favorite ice cream

▶ He delivered a meandering answer on where his grandkids live

President Joe Biden took question after question from school age children at the White House during 'take your child to work day' – where on at least one occasion he had to rely on a kid for help recalling the answer.

The White House set up the event on the South Lawn, and allowed children of some administration employees to ask the president questions.

Biden fielded inquiries on topics ranging from his favorite color to his favorite ice scream, but had to second-guess himself when trying to reel off where all six of his grandchildren live.

What should have been a softball was a question about what country Biden last visited tripped up Biden for a while, as he mentioned instead how many leaders he has met as president. …

https://www.dailymail.co.uk/news/article-12021973/No-wonder-cheat-sheets-Biden-struggles-CHILDRENs-press-conference.html

(The Zoonomia Project is an international effort comparing the genetic blueprints of an array of animals. Some of the discoveries were shared in 11 papers published Thursday, April 27, 2023, in the journal Science.)

Zoonomia:

Genetic research reveals all we share with animals

By comparing the genetic blueprints of an array of animals, scientists are gaining new insights into our own species and all we share with other creatures.

One of the most striking revelations is that certain passages in the instructions for life have persisted across evolutionary time, representing a through line that binds all mammals – including us.

The findings come from the Zoonomia Project, an international effort that offers clues about human traits and diseases, animal abilities like hibernation and even the genetics behind a sled dog named Balto who helped save lives a century ago.

Researchers shared some of their discoveries in 11 papers published Thursday in the journal Science.

David O’Connor, who studies primate genetics at the University of Wisconsin-Madison, said the studies tackle deep questions.

“It’s just the wonder of biology, how we are so similar and dissimilar to all the things around us,” said O’Connor, who wasn’t involved in the research. “It’s the sort of thing that reminds me why it’s cool to be a biologist.”

The Zoonomia team, led by Elinor Karlsson and Kerstin Lindblad-Toh at the Broad Institute of MIT and Harvard, looked at 240 species of mammals, from bats to bison. They sequenced and compared their genomes — the instructions organisms need to develop and grow. …

https://apnews.com/article/zoonomia-project-genetics-animals-f80d1570acf5a97a8ed9e2a1104e74e9

>>18762705

The Zoonomia Project

Zoonomia is applying advances in DNA sequencing technologies to understand how genomes generate the tremendous wealth of animal diversity. We decided on “Zoonomia” as the name for our project — combining Greek terms for “animal” and “governing laws” — because it encapsulates what we aim to discover.

We were not the first to coin this term. In 1794, Erasmus Darwin, eminent physician, and grandfather to Charles Darwin, titled his book “Zoonomia; or the Laws of Organic Life”, and asked

would it be too bold to imagine, that in the great length of time, since the earth began to exist, perhaps millions of years…that all warm-blooded animals have arisen from one living filament…?

Erasmus’s insight is remarkable. Contemporary estimates place Earth’s age in the billions, not millions, of years. But Erasmus was correct that all species are related to one another, with any pair sharing a common ancestor in the distant past. This relationship offers a powerful tool for determining and understanding which parts of a genome are important.

DNA must be copied before it is passed from an ancestor to descendants. Copying is imperfect, so some changes arise over time. Changes that do not cause problems tend to accumulate and DNA sequence slowly drifts away from its initial spelling. Finding segments of DNA unchanged across species is, therefore, a powerful strategy to find those important for all animals.

By sequencing and comparing the genomes of hundreds of diverse mammals, Zoonomia is identifying segments unchanged across all species, as well as segments changed in just a few. We are discovering both the genomic basis of traits essential for all animals and changes that underlie the unique traits of individual species.

To understand human health and treat disease, we must find the genetic underpinnings of complex diseases such as heart disease, arthritis, and schizophrenia. Comparing genomes of patients to healthy controls can identify specific genomic regions that differ, revealing genes involved in disease.

Data from the Zoonomia project are enabling us to assess every position in the genome for variation across 240 different mammalian species. Positions that have stayed the same across most or all of the mammalian species sampled — spanning roughly 100 million years of evolutionary time — likely serve some important function, and hence could cause disease if changed by mutation.

This same approach can be applied to identify the genetic basis of remarkable phenotypes in other mammalian species and to discover mutations that impact their health. Data from the Zoonomia project will therefore allow us to not only to advance human medicine but also to support the health and conservation of species from across the mammalian tree.

We believe that the existing data set will help the interpretation of the human genome and thereby offer an understanding of common and rare human diseases that may lead to both better diagnostics and more specific treatment options.

-Kerstin Lindblad-Toh, Uppsala University and the Broad Institute of MIT and Harvard

https://zoonomiaproject.org/

>>18762705

>Researchers shared some of their discoveries in 11 papers published Thursday in the journal Science.

SCIENCE - VOLUME 380|ISSUE 6643|28 APR 2023 - COVER

Mammals come in a wide variety of shapes and sizes, here represented by some of the least well known and most unusual—clockwise from top left: a fossa, a Hoffmann’s two-toed sloth, a lesser hedgehog tenrec, two tree (or white-bellied) pangolins, and an aye-aye. The Zoonomia project’s sequencing of more than 240 mammal genomes is paving new roads for understanding mammalian diversity and evolution and ourselves.

https://www.science.org/doi/10.1126/science.adi1599

free to read

—

all pay-walled:

PERSPECTIVES

▶ Genomics expands the mammalverse - Diverse mammal genomes open a new portal to hidden aspects of evolutionary history

▶ Seeing humans through an evolutionary lens - A collection of mammalian genomes provides insights into human biology and evolution

RESEARCH ARTICLES

▶Mammalian evolution of human cis-regulatory elements and transcription factor binding sites

​▶Comparative genomics of Balto, a famous historic dog, captures lost diversity of 1920s sled dogs

▶ Relating enhancer genetic variation across mammals to complex phenotypes using machine learning

▶ A genomic timescale for placental mammal evolution

▶ Evolutionary constraint and innovation across hundreds of placental mammals

▶ Leveraging base-pair mammalian constraint to understand genetic variation and human disease

▶ Integrating gene annotation with orthology inference at scale

▶ The functional and evolutionary impacts of human-specific deletions in conserved elements

▶ Three-dimensional genome rewiring in loci with human accelerated regions

▶ Insights into mammalian TE diversity through the curation of 248 genome assemblies

▶ The contribution of historical processes to contemporary extinction risk in placental mammals

https://www.science.org/toc/science/380/6643

>>18762713

>>18762582

>The Protocols of The Elders of Zion!

>>18762606

>https://vault.fbi.gov/protocols-of-learned-elders-of-zion

Famous Russian forgery

KEK

Robert F. Kennedy Jr

I have been litigating for 40 years and the people that broke the law and who illegally forced people to do things, the people that used illegal coercion during the Covid pandemic should be prosecuted. Listen to my interview today with @clayandbuck to hear more of what I said on this issue. #Kennedy24

https://clayandbuck.com/rfk-jr-tells-us-why-he-fears-a-totalitarian-future/

3:29 PM · Apr 27, 2023·171.7K Views

https://twitter.com/RobertKennedyJr/status/1651669993820418057

Ezra A. Cohen Retweeted

Hans Kristensen·2h

Danish defense: Russian special operations vessel was near Nordstream pipelines four days before they were blown up.

https://www.information.dk/indland/2023/04/forsvaret-bekraefter-rusland-specialfartoej-naer-nord-streams-spraengningspunkt

2:25 PM · Apr 27, 2023

https://twitter.com/nukestrat/status/1651653777047298048

LIVE: President Trump in Manchester, NH

https://rumble.com/embed/v2hkcac/?pub=4

https://rumble.com/v2k5rsc-live-president-trump-in-manchester-nh.html

Simon Ateba

Everything on this video about @JoeBiden cheat sheet is a lie from the pit of hell. First, the person asking the question knows it's a lie. The @WhiteHouse often reaches out to reporters including the person asking the question to send 'topics' that end up being 'questions' in advance. The @PressSec then prepares answers and calls on the people who have sent topics in advance and those in the front row.The entire thing is rigged, a show, a sham. Even this question and answer session is a sham. It's known by everyone covering the White House that it's all rigged.

3:55 PM · Apr 27, 2023

https://twitter.com/simonateba/status/1651676411780911104