What is the meaning of the name DeSantis?
The surname Desantis is patronymic in origin, meaning it was based on the first name of a forefather. In this case, Desantis is derived from the Latin word "sanctus," meaning "holy" or "devout," thus the original bearer of the name was known to be a holy and devout person.
https://www.houseofnames.com/desantis-family-crest