Anonymous ID: 386078 June 9, 2023, 3:57 p.m. No.18979831   🗄️.is 🔗kun

>>18979746

this faggot is up to his evil neck in crimes against children and humanity.

There is a special place in hell for this fuckery.

Evil and ugly man inside and out…

He is scared and wants trump out of the way with no power in case he and his hollyweird cohorts.

Anon remembers doing a dig on his tweet mars need children. chek out th 159 and reverseP21

What is P21? ==linked to MRNA and DNA damage, Adrenochrome related.

p21Cip1 (alternatively p21Waf1), also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1, is a cyclin-dependent kinase inhibitor (CKI) that is capable of inhibiting all cyclin/CDK complexes,[5] though is primarily associated with inhibition of CDK2.[6][7] p21 represents a major target of p53 activity and thus is associated with linking DNA damage to cell cycle arrest.[8][9][10] This protein is encoded by the CDKN1A gene located on chromosome 6 (6p21.2) in humans.[11]

--

----

Degradation

p21 is negatively regulated by ubiquitin ligases both over the course of the cell cycle and in response to DNA damage. Specifically, over the G1/S transition it has been demonstrated that the E3 ubiquitin ligase complex SCFSkp2 induces degradation of p21.[30][31] Studies have also demonstrated that the E3 ubiquitin ligase complex CRL4Cdt2 degrades p21 in a PCNA dependent manner over S-phase, necessary to prevent p21 dependent re-replication,[32] as well as in response to UV irradiation.[33] Recent work has now found that in human cell lines SCFSkp2 degrades p21 towards the end of G1 phase, allowing cells to exit a quiescent state, whilst CRL4Cdt2 acts to degrade p21 at a much higher rate than SCFSkp2 over the G1/S transition and subsequently maintain low levels of p21 throughout S-phase.[29]

https://en.wikipedia.org/wiki/P21