Quick Dig: Ivermectin / Dengue

>>18987085 (pb)

>Pharmacists call for approval of horse de-wormer in war on scabies

Dengue outbreak in Peru reaches over [13]0K cases with 200 dead, heightened by El Niño rains

https://nypost.com/2023/06/11/dengue-outbreak-in-peru-reaches-200k-cases-200-dead/

This study aims to confirm the antivirus effectiveness of ivermectin on dengue virus type 2 (DENV-2) in Aedes albopictus (Skuse, 1894), then to explore its potential use in the combating to the dengue epidemics.

Both of quantitatively and qualitatively inhibiting effects of ivermectin have been detected in this study.

with the treatment of ivermectin, the infection rate was reduced by as much as 49.63%

Conclusion: Ivermectin can directly or indirectly inhibit DENV-2 multiplication in Aedes albopictus.

https://pubmed.ncbi.nlm.nih.gov/30452439/

Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3327999/

dengue virus (DENV)

We previously identified the small molecule ivermectin as an inhibitor of HIV-1 integrase nuclear entry, subsequently showing ivermectin could inhibit DENV NS5 nuclear import, as well as limit infection by viruses such as HIV-1 and DENV.

https://www.sciencedirect.com/science/article/abs/pii/S0166354219307211