How much POWER do natural products have?
"Natural products and their derivatives represent a major source for anticancer drug discovery (Qian et al., 2013; Qin et al., 2017). Over the past few decades, about 33.5% of FDA- approved anticancer drug entities are identified from natural products or their derivatives (Newman and Cragg, 2020). Many natural products have been found to exert their anticancer activity by inhibiting oncoproteins (e.g. b-catenin and MDM2) and/or reactivating tumor suppressors (e.g. p53 and Puma) (Li et al., 2013; Qin et al., 2018a; Wang W. et al., 2018; Wang et al., 2020; Zhang J. et al., 2020). It has also been reported that natural products can enhance the chemosensitivity of cancer cells by suppressing the functions of drug resistance-related proteins (Feng et al., 2017; Dong et al., 2020; Yuan et al., 2020). Recent studies have identified several natural products with potent inhibitory effects on the b-catenin signaling and shown promising anticancer efficacy in vitro and in vivo, such as baicalin (Zhou et al., 2017), arctigenin (Lee et al., 2017), and rhein (Liu et al., 2018). In the present review, we comprehensively discuss the natural products that target the b-catenin signaling, their in vitro and in vivo anticancer activities, and underlying molecular mechanisms. Moreover, we summarize known natural- product-based b-catenin-targeting strategies and propose new strategies that may be used to identify more specific and effective b-catenin inhibitors for cancer prevention and therapy."
https://www.frontiersin.org/articles/10.3389/fphar.2020.00984/full