dChan - Q Origins Project Archive

DOD Releases Plan for Implementing Cyber Workforce Strategy

Aug. 3, 2023

In February, Deputy Defense Secretary Kathleen H. Hicks signed the DOD Cyber Workforce Strategy, which sets the foundation for how DOD will foster a cyber workforce capable of executing the department's complex and varied cyber missions.

"The strategy provides a roadmap for the advancement and unified management of the cyber workforce, comprised of about 225,000 highly trained civilians, military and contractor personnel," said Mark Gorak, the principal director for resources and analysis for DOD's chief information officer.

Today, the department released a plan for how it will go about implementing that strategy — the "DOD Cyber Workforce Strategy Implementation Plan."

https://dodcio.defense.gov/Portals/0/Documents/Library/CW-StrategyImplementationPlan.pdf

https://www.defense.gov/News/News-Stories/Article/Article/3482767/dod-releases-plan-for-implementing-cyber-workforce-strategy/

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>>19296284

PLoS One

2013 Aug 28;8(8):e72472.

doi: 10.1371/journal.pone.0072472. eCollection 2013.

Identification of putative steroid receptor antagonists in bottled water: combining bioassays and high-resolution mass spectrometry

Abstract

Endocrine disrupting chemicals (EDCs) are man-made compounds interfering with hormone signaling and thereby adversely affecting human health. Recent reports provide evidence for the presence of EDCs in commercially available bottled water, including steroid receptor agonists and antagonists. However, since these findings are based on biological data the causative chemicals remain unidentified and, therefore, inaccessible for toxicological evaluation. Thus, the aim of this study is to assess the antiestrogenic and antiandrogenic activity of bottled water and to identify the causative steroid receptor antagonists. We evaluated the antiestrogenic and antiandrogenic activity of 18 bottled water products in reporter gene assays for human estrogen receptor alpha and androgen receptor. Using nontarget high-resolution mass spectrometry (LTQ-Orbitrap Velos), we acquired corresponding analytical data. We combined the biological and chemical information to determine the exact mass of the tentative steroid receptor antagonist. Further MS(n) experiments elucidated the molecule's structure and enabled its identification. We detected significant antiestrogenicity in 13 of 18 products. 16 samples were antiandrogenic inhibiting the androgen receptor by up to 90%. Nontarget chemical analysis revealed that out of 24520 candidates present in bottled water one was consistently correlated with the antagonistic activity. By combining experimental and in silico MS(n) data we identified this compound as di(2-ethylhexyl) fumarate (DEHF). We confirmed the identity and biological activity of DEHF and additional isomers of dioctyl fumarate and maleate using authentic standards. Since DEHF is antiestrogenic but not antiandrogenic we conclude that additional, yet unidentified EDCs must contribute to the antagonistic effect of bottled water. Applying a novel approach to combine biological and chemical analysis this is the first study to identify so far unknown EDCs in bottled water. Notably, dioctyl fumarates and maleates have been overlooked by science and regulation to date. This illustrates the need to identify novel toxicologically relevant compounds to establish a more holistic picture of the human exposome.

https://pubmed.ncbi.nlm.nih.gov/24015248/

August 4, 2023

9:30 AM EDT

Secretary of Defense Lloyd J. Austin III provides remarks at a 9 a.m. EDT ceremony at Joint Base Myer-Henderson Hall in recognition of Army Chief of Staff Gen. James C. McConville's relinquishment of authority and Sgt. Maj. of the Army Michael Grinston's change of responsibility

Department of Defense

https://www.defense.gov/News/Today-in-DOD/Date/2023-08-04/

https://www.defense.gov/News/Live-Events/#/?currentVideo=32502

August 4, 2023

10:00 AM EDT

Looking South: A Conversation with GEN Laura Richardson on Security Challenges in Latin America

Center for Strategic and International Studies (CSIS)

https://www.defense.gov/News/Today-in-DOD/Date/2023-08-04/

https://www.csis.org/events/looking-south-conversation-gen-laura-richardson-security-challenges-latin-america

https://www.youtube.com/watch?v=5TNgmqTQNUI

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Gen. Laura Richardson on Security Challenges Facing Latin America

Army Gen. Laura Richardson, commander of the U.S. Southern Command, discusses security challenges facing Latin America during a virtual event hosted by the Center for Strategic and International Studies.

https://www.c-span.org/video/?529756-1/gen-laura-richardson-security-challenges-facing-latin-america