Anonymous ID: 535e3c Oct. 30, 2023, 4:45 p.m. No.19833204   🗄️.is đź”—kun   >>3258 >>3324 >>3334 >>3521 >>3671 >>3721

BREAKING: Potential Mass Shooting Averted at Colorado’s Glenwood Caverns Adventure Park as Heavily Armed Man Wearing Tactical Clothing and IED Explosive Devices Commits Suicide, Authorities Say

Oct. 30, 2023 5:40 pm

 

The Glenwood Caverns Adventure Park in Colorado came perilously close to becoming the site of a calamitous act of violence this past weekend.

 

A 22-year-old man, heavily armed and carrying a cache of explosives, was found dead at Glenwood Caverns Adventure Park on Saturday morning before the park opened to the public, ABC reported.

 

“This morning shortly after 9:00 AM, the Garfield County Sheriff’s Office was dispatched to the Glenwood Caverns Adventure Park for a death investigation. Several First Responders arrived on scene and the investigation ensued. The Glenwood Caverns Adventure Park has been closed to the public in order to preserve evidence and in the best interest of public safety. The public is reminded to stay clear of this area to allow for the necessary road traffic of the first responders and allow them to do their job,” the Garfield County Sheriff’s Office said in a statement on Saturday.

 

According to authorities, this incident could have led to a large-scale tragedy had the man carried out what appeared to be a planned attack.

 

The man was discovered in the women’s restroom of the mountaintop park, located above the Colorado River in western Colorado. Authorities reported he was dressed in tactical clothing and body armor. His arsenal included an AR-style rifle, a handgun, multiple loaded magazines for each weapon, and explosives.

 

Garfield County Sheriff Lou Vallario said that a message was written on a wall of the restroom where the man was found, stating, “I am not a killer, I just want to get into the caves.” However, Vallario could not confirm if the message was left by the suspect.

 

Multiple improvised explosive devices (IEDs) were also found in his vehicle, according to police. A thorough search of the park for additional explosives yielded no further discoveries.

 

The police were investigating the man’s death as a possible suicide.

 

“While this investigation is still ongoing and very active it is important to realize that given the amount of weaponry, ammunition, and explosive devices found, the suspect could have implemented an attack of devastating proportions upon our community and first responders,” said Garfield County Sheriff’s Office spokesperson Walt Stowe.

 

Read the full press release from Garfield Country Sheriff’s Office:

 

On the morning of October 28, 2023, the Garfield County Sheriff’s Office responded to a report of a deceased male at the Glenwood Caverns Adventure Park. The deceased had been located prior to the park opening to the public and was not related to any of the rides or exhibits at the park. Based upon a preliminary investigation it appeared that the suspect illegally entered the park after hours, when no employees or patrons were present.

 

The investigation, which spanned the days of October 28 and 29*, involved a 22-year-old male from the Carbondale area. He was dressed in black colored tactical clothing, bearing patches and emblems that gave the appearance of being associated with law enforcement. The suspect had been heavily armed with a semiautomatic rifle and semi-automatic handgun and multiple, loaded magazines for both weapons. He was wearing body armor and what appeared to be a ballistic helmet. Additionally multiple improvised explosive devices, (IEDs), were discovered with the suspect and in a vehicle associated with the suspect. At the request of the Garfield County Sheriff’s Office, the Grand Junction Bomb Squad responded to the scene and with their expertise were able to render the devices safe.

 

The Glenwood Adventure Caverns property was then swept by members of the bomb squad as well as operators from the Garfield County All Hazard Response Team (AHRT) to ensure no other IED’s had been planted around the park or rides. Our investigation has so far indicated that nobody in the public was at risk; it would appear that the suspect’s actions were limited to the property of the Glenwood Caverns. The initial two days of the investigation have been carried out in a slow, methodical manner in order to search the property, as well as the suspect’s residence to ensure the safety of the public and to begin to determine the extent of his criminal activity. The safety of the public, bomb disposal personnel, law enforcement and other first responders was the priority as well as making sure the Caverns were safe to reopen.

 

While this investigation is still ongoing and very active it is important to realize that given the amount of weaponry, ammunition, and explosive devices found, the suspect could have implemented an attack of devastating proportions upon our community and first responders.

 

https://www.thegatewaypundit.com/2023/10/breaking-potential-mass-shooting-averted-colorados-glenwood-caverns/

Anonymous ID: 535e3c Oct. 30, 2023, 5:33 p.m. No.19833531   🗄️.is đź”—kun   >>3533 >>3541 >>3563 >>3647 >>3671 >>3721 >>3738

Cure for HIV could be months away as first three patients are injected with new CRISPR therapy that seeks and destroys lingering pieces of virus

UPDATED: 18:35 EDT, 30 October 2023

 

After four decades and over 700,000 Americans dead, gene editing experts believe they are on the cusp of curing HIV.

 

Three patients in California have just been injected with genetic material along with an enzyme called CAS9 that early studies suggest can splice sections of the virus’ DNA that become lodged in human cells, eliminating it entirely.

 

Using the gene-editing technology CRISPR, a cure for the AIDS-causing virus could be closer on the horizon than ever thought before.

 

The current trial aims to prove the treatment is safe, but data on how well it work is expected next year.

 

HIV was a near-certain death sentence until the mid-90s, when antiviral medications turned it into a chronic disease that people can live with.

 

In total 1.2 million Americans have HIV and, even with access to medicine, have a risk of seeing their dormant infection resurface and potentially progress to AIDS.

 

Treatment options have evolved considerably since HIV was first identified in the early 80s. The course of treatment went from patients having to take several pills a day that might not even work well to start, to taking just a single daily pill that combines all of the best known therapies into one.

 

These are known as antiretroviral therapies, or daily medications that tamp down the amount of virus in the blood to undetectable levels. These medications are effective, they are not a cure.

 

A cure for HIV has eluded scientists for decades because of the unique way in which the virus hijacks the body's own cells.

 

HIV hides in immune cells in the body, where they can shield themselves from being destroyed by other immune cells. This makes hunting and killing HIV in the body difficult, because there is a risk of damaging healthy cells as well.

 

CRISPR technology is especially promising for situations such as this, because the therapy is extremely targeted to highly specific sections of genetic material within cells.

 

CRISPR stands for Clustered Regularly Interspaced Short Palindromic Repeats. It was adapted from a naturally occurring genome editing system used by bacteria as an immune defense.

 

Researchers create a small piece of 'guide' RNA which binds to specific targets on DNA strands within a cell. Guide RNA, is its name implies, guides the enzyme CAS9 to those targets on DNA.

 

CAS9, like a pair of microscopic scissors, cuts those designated sections of DNA. Once cut and without its key ingredients, the virus can no longer replicate and infect cells.

 

While extremely promising in the field of chronic disease treatment, CRISPR therapy would be exhorbitantly expensive without guarantee of insurance coverage. Novartis, for instance launched a gene therapy for an inherited muscle wasting disease that costs $2.125 million per treatment.

 

Researchers from San Francisco-based biotech firm Excision BioTherapeutics developed the treatment called EBT-101 to be administered to people with HIV who would be followed for about a year.

 

The technology has been injected into three people with HIV so far, with another six to follow, and has been shown to be safe. However, the trial is still in such early stages and efficacy data is expected to come out next year.

 

The three people had been taking an antiretroviral medication to reduce the amount of detectable virus in a person’s blood. They were instructed to stop taking it before the experiment.

 

Excision's injectable gene therapy contained guide RNA that directed CAS9 to the three specific segments of the HIV DNA to be cut. Once those segments are cut, HIV cells lose their ability to replicate and thus become unable to cause infection.

 

Interest in CRISPR technology has resulted in breakthrough research into curing sickle cell anemia, the most common form of inherited blood disorder, and paved the way for the development of treatments for other crippling diseases such as types of cancer.

 

Dr William Kennedy, Senior Vice President of Excision, said the the CRISPR gene therapy did not cause any severe negative side effects. Any side effects that resulted were then resolved on their own.

 

Dr Kennedy told DailyMail.com seperately that the team is 'encouraged by the initial results' which support their ability to advance to the next level where they will trial higher doses of the gene therapy.

 

He said: 'Importantly, these data build on the findings from multiple preclinical studies underscoring the potential of our novel approach in treating chronic latent viral diseases beyond HIV.

 

'Our pipeline includes investigational therapies for Herpes and Hepatitis B.'

 

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Anonymous ID: 535e3c Oct. 30, 2023, 5:33 p.m. No.19833533   🗄️.is đź”—kun   >>3671 >>3721

>>19833531

But the team faces an uphill battle because of the specific way in which HIV lurks in the body and infiltrates healthy cells, using them as shields.

 

The company has yet to report any efficacy data, instead revealing that, at least in early stages, the treatment has been proven safe. Participants are followed for nearly a year, and the trial only began in January 2022.

 

The research team also plans to expand its trial to include administering higher doses of the treatment, which will yield results in 2024.

 

This is also one of the relatively few applications of CRISPR technology to infectious diseases.

 

More often than not, gene editing has been studied to remedy chronic illnesses such as cancer and inherited disorders like sickle cell, and most have entailed removing genetic material to manipulate before reinserting it, making their research unique.

 

A handful of people with HIV have been 'effectively cured'.

 

One such person is a 53-year-old man — known by scientists as the Dusseldorf Patient — who has been off anti-retroviral drugs — tablets usually required daily to keep the virus at bay — for four years without relapse thanks to a risky stem cell transplant.

 

The patient underwent allogeneic hematopoietic stem cell transplantation (HSCT) in February 2013, overseen by an international research team, headed by medics at Dusseldorf University Hospital.

 

Before that, American Timothy Ray Brown, dubbed the 'Berlin patient' because of where he was treated, was declared HIV-free in 2007 after two bone marrow transplants.

 

Mr Brown, who died in 2020 from terminal leukemia, was from Seattle but lived in Germany, was diagnosed with HIV in 1995.

 

In 2006, after more than a decade on standard anti-retroviral therapy to suppress his disease, he was diagnosed with acute myeloid leukemia, a cancer of the blood cells.

 

His doctor at the Charite Hospital in Berlin said his best bet at survival was a bone marrow transplant, which replaces a sick person's immune system with stem cells from the bone marrow of a healthy person.

 

Brown survived his first transplant, and stopped taking his HIV medication that day. He had another transplant in early 2008. On February 2008, he was declared HIV-free at the CROI Conference in Boston.

 

He died at 54 mere days after announcing that he had been battling an aggressive blood cancer for months.

 

And in the UK, the 'London patient', now known to be Adam Castillejo, became the second person ever to be cured of HIV.

 

The patient was diagnosed with HIV in 2003. He started taking anti-retroviral therapy (or, ART, which are virus-suppressing drugs) to control the infection in 2012. Ever since 1996, when ART was discovered, it has been recommended as immediate treatment post-diagnosis. The researchers do not elaborate on why the London patient went nine years before starting on ART.

 

He developed Hodgkin lymphoma that year. In 2016, he agreed to a stem cell transplant to treat the cancer.

 

As with the Berlin patient, the London patient's doctors found a donor with a CCR5 mutation.

 

The transplant changed the London patient's immune system, giving him the donor's mutation and HIV resistance.

 

https://www.dailymail.co.uk/health/article-12689777/Cure-HIV-months-away-three-patients-injected-new-CRISPR-therapy-seeks-destroys-lingering-pieces-virus.html

 

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