Anonymous ID: bf0625 Jan. 7, 2024, 11 a.m. No.20201610   ๐Ÿ—„๏ธ.is ๐Ÿ”—kun   >>1620

https://en.wikipedia.org/wiki/Mauveine

One of the first synthetic dyes, Mauveine was discovered serendipitously while attempting to synthesise the phytochemical quinine for the treatment of malaria.

Anonymous ID: bf0625 Jan. 7, 2024, 11:06 a.m. No.20201636   ๐Ÿ—„๏ธ.is ๐Ÿ”—kun

>>20201620

>Mauve

Between 1859 and 1861, mauve became a fashion must have. The weekly journal All the Year Round described women wearing the colour as "all flying countryward, like so many migrating birds of purple paradise". Punch magazine published cartoons poking fun at the huge popularity of the colour โ€œThe Mauve Measles are spreading to so serious an extent that it is high time to consider by what means they may be checked.โ€

 

Laborers in the aniline dye industry were later found to be at increased risk of bladder cancer, specifically transitional cell carcinoma, yet by the 1950s, the synthetic dye industry had helped transform medicine, including cancer treatment.

Anonymous ID: bf0625 Jan. 7, 2024, 11:10 a.m. No.20201656   ๐Ÿ—„๏ธ.is ๐Ÿ”—kun   >>1673

https://en.wikipedia.org/wiki/Gin_and_tonic

He was actually trying to develop a synthetic alternative to the anti malaria drug quinine but realized that his experiment had produced a vivid purple shade.

Anonymous ID: bf0625 Jan. 7, 2024, 11:15 a.m. No.20201682   ๐Ÿ—„๏ธ.is ๐Ÿ”—kun

Queen Victoria appeared at the 1862 Royal Exhibition in a gown of vivid mauveine, and her granddaughter, the Empress Alexandra of Russia would be a massive fan of the color mauve.

 

It wasnโ€™t all jollity though โ€“ after some controversy arose about the safety of synthetic dyes, a German chemist tested fabrics dyed with magenta in the early 1870s and found that they contained traces of arsenic and there were also increasing reports of clothes dyed in this way causing skin conditions as the dye leaked out as a result of perspiration, rain or just general domestic laundry practices. However, the popularity of aniline dyes continued and eventually the dye would be approved as food colouring, while aniline itself would go on to be developed as an analgesic drug.

Anonymous ID: bf0625 Jan. 7, 2024, 11:31 a.m. No.20201767   ๐Ÿ—„๏ธ.is ๐Ÿ”—kun   >>1821

Quinine was used as a muscle relaxant by the Quechua people, who are indigenous to Peru, Bolivia and Ecuador, to halt shivering. The Quechua would mix the ground bark of cinchona trees with sweetened water to offset the bark's bitter taste, thus producing something similar to tonic water.

Spanish Jesuit missionaries were the first to bring cinchona to Europe. The Spanish had observed the Quechua's use of cinchona and were aware of the medicinal properties of cinchona bark by the 1570s or earlier: Nicolรกs Monardes (1571) and Juan Fragoso (1572) both described a tree, which was subsequently identified as the cinchona tree, whose bark was used to produce a drink to treat diarrhea. Quinine has been used in unextracted form by Europeans since at least the early 17th century.

During the 17th century, malaria was endemic to the swamps and marshes surrounding the city of Rome. It had caused the deaths of several popes, many cardinals and countless common Roman citizens. Most of the Catholic priests trained in Rome had seen malaria patients and were familiar with the shivering brought on by the febrile phase of the disease.

The Jesuit Agostino Salumbrino (1564โ€“1642), an apothecary by training who lived in Lima (now in present-day Peru), observed the Quechua using the bark of the cinchona tree to treat such shivering. While its effect in treating malaria (and malaria-induced shivering) was unrelated to its effect in controlling shivering from rigors, it was a successful medicine against malaria. At the first opportunity, Salumbrino sent a small quantity to Rome for testing as a malaria treatment. In the years that followed, cinchona bark, known as Jesuit's bark or Peruvian bark, became one of the most valuable commodities shipped from Peru to Europe. When King Charles II was cured of malaria at the end of the 17th Century with quinine, it became popular in London. It remained the antimalarial drug of choice until the 1940s, when other drugs took over.

 

In 1994, the FDA banned the marketing of over-the-counter quinine as a treatment for nocturnal leg cramps. Pfizer Pharmaceuticals had been selling the brand name Legatrin for this purpose.