🕯NarfGB

@NarfGb

https://sciencedirect.com/science/article/abs/pii/S0022519313000799

"It won't be bad. It's no problem."™

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Karl Childers 🐭 🍟

@CumberpatchM

·

Jan 19

Ever since I posted this obscure research paper

I think I'm being shadow banned

https://sciencedirect.com/science/article/abs/pii/S0022519313000799

12:46 AM · Jan 20, 2024

https://twitter.com/NarfGb/status/1748597925947511191

Frameshifted prion proteins as pathological agents: Quantitative considerations

https://www.sciencedirect.com/science/article/abs/pii/S0022519313000799

Abstract

A quantitatively consistent explanation for the titres of infectivity found in a variety of prion-containing preparations is provided on the basis that the ætiological agents of transmissible spongiform encephalopathy comprise a very small population fraction of prion protein (PrP) variants, which contain frameshifted elements in their N-terminal octapeptide-repeat regions. A mechanism for the replication of frameshifted prions is described and calculations are performed to obtain estimates of the concentration of these PrP variants in normal and infected brain, as well as their enrichment in products of protein misfolding cyclic amplification. These calculations resolve the lack of proper quantitative correlation between measures of infectivity and the presence of conformationally-altered, protease-resistant variants of PrP. Experiments, which could confirm or eventually exclude the role of frameshifted variants in the ætiology of prion disease, are suggested.