Anonymous ID: 1fce11 Feb. 4, 2024, 2:10 p.m. No.20357281   🗄️.is 🔗kun   >>7303 >>7500 >>7600 >>7738 >>7882 >>8002 >>8054 >>8121

https://twitter.com/ThailandMedicaX/status/1754125716839620619

 

Thailand Medical News

@ThailandMedicaX

Texas MD Anderson Cancer Center Warns That COVID-19 mRNA Vaccines Elevate PD-L1 Levels, Disrupting Lung Cancer Treatments, Progressing Other Cancers!

 

https://thailandmedical.news/news/texas-md-anderson-cancer-center-warns-that-covid-19-mrna-vaccines-elevate-pd-l1-levels-disrupting-lung-cancer-treatments-progressing-other-cancers

 

#BreakingNews #MedicalNews #News #COVID19 #vaccines #mRNA #Cancer #SARS #America #USA #Ottawa #France

thailandmedical.news

Texas MD Anderson Cancer Center Warns That COVID-19 mRNA Vaccines Elevate PD-L1 Levels, Disrupting…

6:52 AM · Feb 4, 2024

Anonymous ID: 1fce11 Feb. 4, 2024, 2:14 p.m. No.20357303   🗄️.is 🔗kun

>>20357281

https://www.thailandmedical.news/news/texas-md-anderson-cancer-center-warns-that-covid-19-mrna-vaccines-elevate-pd-l1-levels-disrupting-lung-cancer-treatments-progressing-other-cancers

 

Texas MD Anderson Cancer Center Warns That COVID-19 mRNA Vaccines Elevate PD-L1 Levels, Disrupting Lung Cancer Treatments, Progressing Other Cancers!

Nikhil Prasad Fact checked by:Thailand Medical News Team Feb 04, 2024 9 hours, 25 minutes ago

Medical News: In the ongoing battle against the COVID-19 pandemic, mRNA vaccines have played a pivotal role in curbing the spread of the virus. However, recent research from the University of Texas MD Anderson Cancer Center-USA has shed light on a potential complication for patients with advanced non-small cell lung cancer (NSCLC). The study suggests that mRNA COVID-19 vaccines may elevate the levels of PD-L1 expression, impacting the effectiveness of immune checkpoint inhibitors in treating NSCLC.

 

 

Researchers from MD Anderson presented their findings lats year during the 2023 World Conference on Lung Cancer in Singapore last September.

https://cattendee.abstractsonline.com/meeting/10925/Session/114

(look at presentation MA.15.04 Dr A. Grippin.)

 

The abstract is published in the peer reviewed Journal of Thoracic Oncology.

https://www.jto.org/article/S1556-0864(23)01024-9/fulltext

 

The full study was never published as it was speculated (We have no evidence if this speculation is valid or not as it came from a staff member of the center that wishes to remain anonymous) that there was intense lobbying by certain pharma companies that have been supporting the University and the cancer center. There were also speculations that attempts were made to prevent media coverage of this important findings. (however there are other teams in various countries working on similar research and more data will be released soon which shows not just PD-L1 levels being affected but also other oncogenic genes are also elevated while tumor protective genes are being downregulated!)

p1

Anonymous ID: 1fce11 Feb. 4, 2024, 2:14 p.m. No.20357304   🗄️.is 🔗kun

>>2

 

This Medical News report delves into the findings of this research by MD Anderson, exploring the implications for lung cancer treatments and the potential repercussions for other cancer types.

 

Understanding PD-L1 Expression and Immune Checkpoint Inhibition

PD-L1, or programmed death-ligand 1, is a protein that plays a crucial role in regulating the immune system. In the context of cancer, increased PD-L1 levels can create an immunosuppressive microenvironment, allowing cancer cells to evade detection and destruction by the immune system. Immune checkpoint inhibitors, such as anti-PD-1/PD-L1 therapies, have emerged as a promising treatment for advanced NSCLC by blocking the PD-1/PD-L1 interaction and unleashing the immune system to target cancer cells.

 

The Research Findings

Dr Adam Grippin and his colleagues at the University of Texas MD Anderson Cancer Center conducted a comprehensive study to investigate the impact of mRNA COVID-19 vaccines on PD-L1 expression in patients with advanced NSCLC. The research involved the analysis of biopsy samples from 2216 NSCLC patients who had undergone biopsies between January 2017 and August 2022.

 

The patients were divided into four groups based on the interval between COVID-19 vaccination and the biopsy date. Notably, the study revealed a significant association bet ween the time elapsed since vaccination and the PD-L1 tumor proportion score (TPS). Patients who had a biopsy 70-99 days after COVID-19 vaccination exhibited a substantially higher average PD-L1 TPS (40%) compared to those who had a biopsy 0-69 days from vaccination (25%) or 100 or more days from vaccination (21%).

 

Furthermore, patients in the 70-99 days group demonstrated a higher proportion of samples with a PD-L1 TPS of 50% or higher, indicating a potential impact on the clinical management of these patients. The study emphasized that the elevation of PD-L1 expression was time-dependent, prompting the need for further investigation into the underlying mechanisms and the relationship between the timing of COVID mRNA vaccines and clinical responses to immune checkpoint blockade.

 

Implications for Lung Cancer Treatment

The observed increase in PD-L1 expression following mRNA COVID-19 vaccination raises important considerations for the treatment of advanced NSCLC. The effectiveness of immune checkpoint inhibitors, which relies on the inhibition of the PD-1/PD-L1 interaction, may be influenced by the heightened PD-L1 levels induced by the vaccine.

 

Dr Grippin highlighted the potential significance of these findings in the clinical setting. The elevated PD-L1 expression could potentially restore sensitivity to immune checkpoint inhibition in patients with resistant NSCLC, providing a valuable avenue for further research and personalized treatment strategies.

 

Broader Impact on Cancer Progression

Beyond NSCLC, the implications of elevated PD-L1 expression extend to various other malignancies. The immunosuppressive tumor microenvironment created by increased PD-L1 levels may facilitate the evasion of cancer cells from immune surveillance and lead to accelerated progression in cancers such as hepatocellular carcinoma, pancreatic cancer, gastric cancer, renal cell cancer, esophageal cancer, and ovarian cancer.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990391/

 

This suggests a need for a nuanced approach to vaccination strategies in cancer patients, considering the potential impact on the immune landscape. The findings prompt a reevaluation of the risks and benefits of mRNA COVID-19 vaccines in patients with existing cancer diagnoses.

 

Future Directions and Conclusion

The research findings from the opens new avenues for investigation into the intricate relationship between mRNA COVID-19 vaccines, PD-L1 expression, and the clinical outcomes of cancer patients. Understanding the mechanisms behind the time-dependent increase in PD-L1 levels is crucial for optimizing the use of immunotherapies in the context of vaccination.

 

Further research will be instrumental in delineating the precise impact of mRNA COVID-19 vaccines on the immune landscape of cancer patients, guiding the development of tailored treatment approaches and ensuring the optimal care for individuals facing both viral and oncological challenges.

2 of 2

Anonymous ID: 1fce11 Feb. 4, 2024, 2:15 p.m. No.20357305   🗄️.is 🔗kun   >>7374

https://twitter.com/WayneGb88/status/1753896154842943950

 

Sick Of It 🇬🇧🇬🇧🇺🇸🇺🇸

@WayneGb88

Pakistan's Council of Islamic Ideology concluded that children can be married and raped as soon as they menstruate

 

Pakistan is the fucking toilet of earth

3:40 PM · Feb 3, 2024

·

Anonymous ID: 1fce11 Feb. 4, 2024, 2:17 p.m. No.20357325   🗄️.is 🔗kun   >>7341 >>7500 >>7600 >>7738 >>7882 >>8002 >>8054 >>8121

France Caves To Farmers As Ireland 'Solidarity' Protests Kick Off

 

https://www.zerohedge.com/geopolitical/france-caves-farmers-ireland-solidarity-protests-kick

 

Two of France's main farming unions on Thursday agreed to suspend protests and lift road blockades across the country after the government announced measures the deemed "tangible progress" in the ongoing revolt against EU 'climate-driven' initiatives designed to wean society off of evil, non-bug-based, carbon-emitting food while China, India, and the rest of the world laughs.

 

 

In addition to France, protests have been held in Belgium, Portugal, Greece, Germany and elsewhere. Last week, tensions came to a head in Brussels when farmers threw eggs and stones at the European Parliament building, demanding that European leaders stop punishing them with more taxes and rising costs to finance the so-called 'green agenda.'

 

After French farmers stepped up protests earlier in the week, the government promised on Thursday to extend protections - including better controlling imports and giving farmers additional aid, Reuters reports.

 

"Everywhere in Europe the same question arises: how do we continue to produce more but better? How can we continue to tackle climate change? How can we avoid unfair competition from foreign countries?," said Prime Minister Gabriel Attal, announcing the new measures.

 

In response, France's main farmers union, FNSEA, announced that it was time to lift the blockades and "go home." Arnaud Gaillot of the Young Farmers' union echoed the message, however both unions warned that other types of protests would continue, and they'd be back if the government doesn't make good on their promises.

 

Meanwhile in Ireland, farmers began protesting Thursday evening.

 

#BREAKING #Ireland JUST IN: Farmers' protests began in Ireland. pic.twitter.com/rJ6lsCnkgG

 

— The National Independent (@NationalIndNews) February 1, 2024

"There’s a general dissatisfaction with the level of environmental regulation that is being heaped on farmers, the low margins, and (the) resulting low income the farmers have been suffering from for a very long time now," said Cathal MacCarthy, media director for the Irish Creamery Milk Suppliers Association, adding "There will be a great deal of sympathy and solidarity with the aim and ambitions of the protests both in Ireland and on the Continent," EURACTIV reports.

 

 

"They feel they are being regulated out of business by Brussels bureaucrats and Department of Agriculture officials who are far removed from the reality of day-to-day farming," said Irish Farmers’ Association (IFA) President Francine Gorman on Wednesday, ahead of the protests.

 

The concerns of the Irish beef and dairy farmers echo the concerns of other European farmers who have been protesting for weeks.

 

MacCarthy said Irish beef and dairy farmers also believe they are not being compensated fairly for the agrifood products they cultivate, given the increased costs involved in production as a result of environmental regulations.

 

“We need senior politicians to face consumers and say, ‘Lads, listen, the cost of producing this food is X, that has to be paid, and the margin that allows farmers to live (has to be paid), but we can’t just be dependent on what the supermarket feels like charging their customers,’” he said. -EURACTIV

 

"We can either continue to have cheap food, or we can have environmentally sustainable food, but we can’t have both," said MacCarthy.

Anonymous ID: 1fce11 Feb. 4, 2024, 2:18 p.m. No.20357332   🗄️.is 🔗kun

https://twitter.com/nxt888/status/1753824922244374532

 

Sony Thang

@nxt888

🇺🇸OLIVER STONE:

 

"Netanyahu is a mad man; I repeat that. To me, he's a mad man.

 

I met him years ago; I interviewed him when he was out of office. I thought he was a mad man then and I think he's gotten worse and worse. He's truly insane.

 

I've never seen such slaughter being justified like this, as revenge.

 

How do you wipe out a political movement? It's never been done in the history of the world.

 

How are you going to kill off everybody? What do you do, separate them, send them to Egypt? It's just mad, the whole solution.

 

And what was sickening to me was when Biden went over there, hat in hand and money in hand, to give him what he wanted. This is the problem with our country.

 

In that regard, I think Trump, although he supported Israel to a max and made quite a few mistakes in that regard, has better choices to make.

 

We can't do this, we can't constantly support Israel. We have to say no, cut them off, cut off everything to them right now. That's what I would do.

 

And don't give me this anti-Semitic shit… I mean, I don't even know what they're talking about.

 

Who are the anti-Semites in the world? Just a few nutcases. Nobody's an anti-Semite unless they have a problem with Hitler and all that.

 

But this is an issue about justice and peace and balance and basic human decency.

 

I don't understand how they can kill Palestinians like this. And now apparently, they're killing… I mean, 20,000 was the last number I heard.

 

[It's 24,000 now.]

 

Oh, gross. Jesus, I mean, it's sad.

 

I don't know what to do. You can't go over there because they shoot you.

 

When I was over there, it's funny because it seemed to me at that time in June that everything was kind of quieting down, right? That was the time when it just seemed like nothing was happening. It appeared to be settling down as an issue. I was hoping that would change, but it has gotten worse."

10:57 AM · Feb 3, 2024

Anonymous ID: 1fce11 Feb. 4, 2024, 2:19 p.m. No.20357339   🗄️.is 🔗kun   >>7351 >>7359

Disclose.tv

@disclosetv

NEW - Thousands of Swedes marched in Stockholm to protest taxpayer-funded news channels, accusing them of spreading "extreme ideologies and misinformation."

From

Christian Peterson 🇸🇪

4:28 PM · Feb 3, 2024

 

https://twitter.com/disclosetv/status/1753908463783047541

Anonymous ID: 1fce11 Feb. 4, 2024, 2:23 p.m. No.20357361   🗄️.is 🔗kun   >>7371 >>7384 >>7413 >>7500 >>7600 >>7738 >>7882 >>8002 >>8054 >>8121

Concerned Citizen

@BGatesIsaPyscho

🚨🇬🇧UK Farmers are go

 

Please let’s see them take over Westminster in protest of our WEF sell out Agenda 2030 Government & their Climate Communism legislation.

 

Support the Farmers they feed us*

 

*unless you’re a fan of Eating bugs & Bill Gates fake meat of course.

8:59 AM · Feb 4, 2024

 

https://twitter.com/BGatesIsaPyscho/status/1754157732540690526