Anonymous ID: 467709 July 4, 2018, 10:05 p.m. No.2037798   🗄️.is 🔗kun   >>7816 >>7826 >>8113 >>8375 >>8542

“metformin by itself increases the formation of Β-amyloid”

 

—Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription

 

—Metformin increases APP expression and processing via oxidative stress, mitochondrial dysfunction and NF-κB activation

 

—Biological and biophysics aspects of metformin-induced effects: cortex mitochondrial dysfunction and promotion of toxic amyloid pre-fibrillar aggregates

 

—Metformin Facilitates Amyloid-β Generation by β- and γ-Secretases via Autophagy Activation.

 

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656178/

 

https://www.sciencedirect.com/science/article/pii/S0167488915000324

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5032692/

 

https://www.ncbi.nlm.nih.gov/pubmed/26967226

 

http://medcraveonline.com/EMIJ/EMIJ-04-00091.pdf

Anonymous ID: 467709 July 4, 2018, 10:14 p.m. No.2037880   🗄️.is 🔗kun   >>7918 >>8375 >>8542

“metformin by itself increases the formation of Β-amyloid”

 

—Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription

 

—Metformin increases APP expression and processing via oxidative stress, mitochondrial dysfunction and NF-κB activation

 

—Biological and biophysics aspects of metformin-induced effects: cortex mitochondrial dysfunction and promotion of toxic amyloid pre-fibrillar aggregates

 

—Metformin Facilitates Amyloid-β Generation by β- and γ-Secretases via Autophagy Activation.

 

—Emerging wastewater contaminant metformin causes intersex and reduced fecundity in fish

 

—Age-dependent effects in fathead minnows from the anti-diabetic drug metformin

 

—Occurrence of the antidiabetic drug Metformin and its ultimate transformation product Guanylurea in several compartments of the aquatic cycle

 

—A global perspective on the use, occurrence, fate and effects of anti-diabetic drug metformin in natural and engineered ecosystems

 

—Metformin and Other Pharmaceuticals Widespread in Wadeable Streams of the Southeastern United States

 

—Adsorption of emerging contaminant metformin using graphene oxide

 

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656178/

 

https://www.sciencedirect.com/science/article/pii/S0167488915000324

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5032692/

 

https://www.ncbi.nlm.nih.gov/pubmed/26967226

 

http://medcraveonline.com/EMIJ/EMIJ-04-00091.pdf

 

https://www.sciencedirect.com/science/article/pii/S0045653515002830?via%3Dihub

 

https://www.sciencedirect.com/science/article/pii/S0016648015300642?via%3Dihub

 

https://www.sciencedirect.com/science/article/pii/S0160412014001512?via%3Dihub

 

https://www.sciencedirect.com/science/article/pii/S0269749116306145

 

https://www.researchgate.net/publication/305010364_Metformin_and_Other_Pharmaceuticals_Widespread_in_Wadeable_Streams_of_the_Southeastern_United_States

 

http://ee.hnu.cn/eeold/php/news/pic/yunfeirandompic_1493040077.pdf

Anonymous ID: 467709 July 4, 2018, 10:21 p.m. No.2037956   🗄️.is 🔗kun   >>7976 >>8113 >>8375 >>8542

>>2037826

 

Metformin induces beta amyloid, is the world's most prevalent contaminant (EPA has zero waste water regulations for it or its ultimate transformation product) and it also down-regulates transcription factor MafA (key transcription factor of the insulin gene) so Metformin also destroys pancreatic beta cells by doing that, inducing and/or facilitating diabetes