In the 1996 action film, Eraser, the film's finale and ending battle take place on and around a Russian cargo ship in the Port of Baltimore, referred to in the movie as the "Baltimore Docks".
The Port of Baltimore appeared in the 2002 thriller movie, The Sum of All Fears.
The second season of the HBO series The Wire centers around activity at the Port of Baltimore.
The first season of the Amazon Prime series Jack Ryan features the Port of Baltimore. The antagonists smuggle Cesium-137 into the port for a terror attack plot.