Int J Mol Sci. 2024 Jul; 25(13): 7137.
Cutaneous Wound Healing and the Effects of Cannabidiol
Published online 2024 Jun 28. doi: 10.3390/ijms25137137
PMCID: PMC11241632
PMID: 39000244
… We also present data from our primary investigations, testing the hypothesis that cannabidiol can alter cutaneous wound healing and documenting their effects in wild type (C57/BL6) and db/db mice (Type 2 Diabetes Mellitus, T2DM). The focus is on the potential roles of the endocannabinoid system, cannabidiol, and the important immune-regulatory wound cytokine IL-33, a member of the IL-1 family, and connective tissue growth factor, CTGF, due to their roles in both normal and abnormal wound healing. We found an initial delay in the rate of wound closure in B6 mice with CBD, but this difference disappeared with time. CBD decreased IL-33 + cells in B6 by 70% while nearly increasing CTGF + cells in db/db mice by two folds from 18.6% to 38.8% (p < 0.05) using a dorsal wound model.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11241632/