DEMENTIA & ALZHEIMER'S CURE: Fungal Infection in the Brain Produces Effects Similar to Alzheimer's
https://www.2ndsmartestguyintheworld.com/p/dementia-and-alzheimers-cure-fungal
Some researchers have suggested that neurodegenerative diseases like Alzheimer's, Parkinson's, and multiple sclerosis may have a microbial origin; thus, inexpensive repurposed drugs may be the cure.
A recent article by The Epoch Times posited that fungal infections may be the cause of neurodegenerative diseases. ( https://www.theepochtimes.com/article/fungal-infections-kill-millions-yet-few-effective-treatments-are-available-5200509 )
A team of researchers at Baylor College of Medicine has discovered that when the brain is infected with a common fungus, it changes in ways similar to those seen in Alzheimer’s disease. The new research delves deeper into some of the molecular mechanisms behind that process.
The Study Findings
Using animal models, the research team discovered how the fungus, called Candida albicans (C. albicans), enters the brain, activates mechanisms for its clearance, and generates amyloid beta (Aβ)-like peptides—toxic protein fragments thought to be central to the development of Alzheimer’s disease.
The findings were published Oct. 10 in the journal Cell Reports.
Previous research has implicated fungi in the development of chronic neurodegenerative diseases like Alzheimer’s disease, but their mechanisms are not entirely understood.
We know that Candida thrives on sugars, so diets high in processed foods and junk foods may very well be feeding the funguses that in turn destroy brains.
We also know that the inexpensive and repurposed drug Fenbendazole (Mebendazole being the analog drug with the addition of a single molecule which adds nothing save for bogus patent-based profits) eradicates these funguses; for example, a research study entitled, The Anti-helminthic Compound Mebendazole Has Multiple Antifungal Effects against Cryptococcus neoformans stated the following:
Cryptococcus neoformans is the most lethal pathogen of the central nervous system. The gold standard treatment of cryptococcosis, a combination of amphotericin B with 5-fluorocytosine, involves broad toxicity, high costs, low efficacy, and limited worldwide availability. Although the need for new antifungals is clear, drug research and development (R&D) is costly and time-consuming. Thus, drug repurposing is an alternative to R&D and to the currently available tools for treating fungal diseases. Here we screened a collection of compounds approved for use in humans seeking for those with anti-cryptococcal activity. We found that benzimidazoles consist of a broad class of chemicals inhibiting C. neoformans growth. Mebendazole and fenbendazole were the most efficient antifungals showing in vitro fungicidal activity. Since previous studies showed that mebendazole reaches the brain in biologically active concentrations, this compound was selected for further studies. Mebendazole showed antifungal activity against phagocytized C. neoformans, affected cryptococcal biofilms profoundly and caused marked morphological alterations in C. neoformans, including reduction of capsular dimensions. Amphotericin B and mebendazole had additive anti-cryptococcal effects. Mebendazole was also active against the C. neoformans sibling species, C. gattii. To further characterize the effects of the drug a random C. gattii mutant library was screened and indicated that the antifungal activity of mebendazole requires previously unknown cryptococcal targets. Our results indicate that mebendazole is as a promising prototype for the future development of anti-cryptococcal drugs.
Thus, we may extrapolate that Fenbendazole, being a powerful antifungal, may quickly and permanently reverse these kinds of neurodegenerative diseases, especially since, “…mebendazole reaches the brain in biologically active concentrations…”
And precisely because C. albicans has been shown to generate toxic protein fragments like amyloid beta (Aβ)-like peptides in the brain,Fenbendazole would be an especially strong candidate for potential therapeutic use in Alzheimer's treatment.