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Interleukin 11

Interleukin 11 (IL-11 or adipogenesis inhibitory factor[5]) is a protein that in humans is encoded by the IL11 gene.[6]

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A recombinant form of IL-11, oprelvekin, is a protein therapeutic used for the prevention of severe thrombocytopenia in cancer patients.[19][20]

As IL-11 over-expression is associated with a number of cancers, inhibition of its signaling pathway may have utility in treating cancer,[21] and has also been researched for its potential ability to slow down aging.[22][23]

Transforming growth factor β1 (TGFβ1) through up-regulation of IL-11, stimulates collagen production and is important in wound healing. However dysregulation of TGFβ1 and downstream IL-11 is associated with fibrotic diseases hence inhibition of IL-11 may have utility in treating fibrosis.[10] This cytokine promotes recruitment of immune suppressive cancer-associated fibroblasts to tumors and facilitates chemoresistance.[24]

It is also under investigation as a way to allow diabetes-damaged kidney tissue to regenerate.[A recombinant form of IL-11, oprelvekin, is a protein therapeutic used for the prevention of severe thrombocytopenia in cancer patients.[19][20]

Other sources anon has posted in the past discuss organ regeneration by inhibiting interleukin-11. The animal testing yielded zero negative side effects, no animals died. This is currently being tested in some humans.

https://en.wikipedia.org/wiki/Interleukin_11