Anonymous ID: 31f959 Sept. 13, 2024, 11:39 p.m. No.21588285   🗄️.is đź”—kun

Arteriosklerose: Cyclodextrin fördert Plaqueabbau

Wenn allmählich die Schlagadern verhärten und sich entzünden, wird es gefährlich. Die Folgen der Arteriosklerose zählen zu den häufigsten Todesursachen in Industrieländern: dazu zählen vor allem Herzinfarkte und Schlaganfälle. Kristallines Cholesterin kann zu den lebensgefährlichen Entzündungen in den Arterien beitragen. Ein internationales Forscherteam hat herausgefunden, dass der ringförmige Zucker „Cyclodextrin“ die gefährlichen Ablagerungen verhindern und sogar zurückbilden kann.

https://mt-portal.de/aktuell/cyclodextrin-foerdert-plaqueabbau/

 

Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming

Dissolving away cholesterol

Cardiovascular disease resulting from atherosclerosis is one of the most common causes of death worldwide, and additional therapies for this disease are greatly needed because not all patients can be effectively treated with existing approaches. Cyclodextrin is a common FDA-approved substance that is already used as a solubilizing agent to improve delivery of various drugs.

Now, Zimmer et al. have discovered that cyclodextrin can also solubilize cholesterol, removing it from plaques, dissolving cholesterol crystals, and successfully treating atherosclerosis in a mouse model. Because cyclodextrin is already known to be safe in humans, this drug is now a potential candidate for testing in human patients for the treatment of atherosclerosis.

Atherosclerosis is an inflammatory disease linked to elevated blood cholesterol concentrations. Despite ongoing advances in the prevention and treatment of atherosclerosis, cardiovascular disease remains the leading cause of death worldwide.

https://pubmed.ncbi.nlm.nih.gov/27053774/

https://www.science.org/doi/10.1126/scitranslmed.aad6100