Anonymous ID: c517bd Nov. 17, 2024, 7:03 p.m. No.22007156   🗄️.is 🔗kun

>>22007100

>phenylephrine

The rise and fall of a fake decongestant: What phenylephrine tells us about the history of the FDA

November 29, 2023

American Chemical Society (ACS)

 

The FDA drug approval process is known to be a lengthy and rigorous one. But the FDA-approved ingredient phenylephrine — found in common cold medicines like Sudafed, Mucinex, and NyQuil — was recently found to be no better than a placebo. Phenylephrine has been on store shelves for nearly 90 years. How could that happen?

 

… there’s a good chance that your preferred cold medicine contains a decongestant called phenylephrine. In fact, in 2022, at least 250 products containing phenylephrine were sold in the US, and they brought in around $1.8 billion in sales. But in September of this year, an advisory panel for the Food and Drug Administration released a report that said that oral phenylephrine—this incredibly popular ingredient—was no better than a placebo.

 

There are two nasal decongestants that you can get without a prescription: phenylephrine and pseudoephedrine. But in the 2000s, pseudoephedrine was moved behind the counter due to concerns about its use to make methamphetamine. You could still get the drug without a prescription, but you would have to show an ID and ask a pharmacist to get it for you.

 

But while their research kept turning up signs that phenylephrine was not an effective oral medication, it took a while to get the FDA to listen to them.

 

At first, the FDA reiterated their approval of phenylephrine from the 1970s. It took a lot of work on the part of these pharmacists to gather data from older studies and be on the lookout for new studies related to phenylephrine. But eventually, an FDA advisory committee called for more data, which was followed by multiple large clinical trials and lots of data for the committee to look over.

 

So from the data they presented, it turns out that this was no better than a placebo or a sugar pill.

https://www.acs.org/pressroom/tiny-matters/fda-approved-phenylephrine-in-cold-medicines.html

Anonymous ID: c517bd Nov. 17, 2024, 7:14 p.m. No.22007225   🗄️.is 🔗kun

>>22007145

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