There's been a propaganda campaign to scare people away from boron despite it having a higher LD-50 than table salt.
Archives of Toxicology
https://doi.org/10.1007/s00204-018-2296-7
Boric acid and sodium borates are currently classified in the EU-CLP regulation as “toxic to reproduction” under “Category
1B”, with hazard statement of H360FD. However, so far field studies on male reproduction in China and in Turkey could not
confirm such boron-associated toxic effects.
10.1016/S0002-8223(99)00085-1
As of 1999 the boron intake for American men ranged from 0.46 mg/d to 2.74 mg/d
https://doi.org/10.52418/moldovan-med-j.64-5.21.14
UDC: 546.27:616.71/.72
Looks like water quality requirements by the government may have caused
osteoporosis and arthritis.
In the past, the poor knowledge of B in the human health conducted that
[65] established a permissible level of B in drinking water of 0.3-0.5 mg B
L-1, this value was so impractical that the European Community (EC) could not meet
with this rule, and changed it to 1.0 mg B L -1, and permitted that their
members countries to adjust it on basis of the quality of its water sources
[66].
According to recently published research, people older
than 40 can prevent/or correct arthritis, osteoporosis and
osteoarthritis by taking B equal to or higher that 3 mg
per day. In the countries following the famous healthy
Mediterranean diet that includes staple foods rich in B such
as grape, broccoli, garlic, tomato, pomegranate and olives
combined with the consumption of drinking water with
high levels of B, daily intake of this trace mineral frequently
results higher than 13 mg per day [8].
Epidemiologic evidence suggests that in the areas of
the world where boron intakes usually were 1 mg or less /
day, the estimated incidence of arthritis ranged from 20 to
70%. On the other hand, in areas of the world where boron
intakes were usually 3 to 10 mg, the estimated incidence of
arthritis ranged from 0 to 10% [10].
Another study has shown that boron levels, along with
those of lead and zinc, were reduced in patients with osteo-
arthritis of the hip when those patients went for hip replace-
ment.
Following the results of a double-blind randomized
placebo-controlled clinical trial with 60 days supplementation
period with calcium fructoborate and sodium tetraborate
for 72 Iraqi patients with active rheumatoid arthritis (RA)
maintained on etanercept, boron as an adjuvant has potenti-
ated therapeutic outcomes in RA patients by improvement
of the clinical scores and significantly decreases the inflam-
matory markers in RA patients [28].
The safety of boron supplements when used in pharma-
cological doses as adjuvant with etanercept in treatment of
RA patients was studied and the results showed that boron
supplements – calcium fructoborate and sodium tetraborate
have no negative impact on erythrocyte sedimentation rate,
hemoglobin, white blood cells, platelets count, hepatic and
renal functions
On average, dried fruits, nuts and avocados contain
between 1 and 4.5 mg of boron/100 g. Fresh fruits, vegetables,
and honey, contains between 0.1 to 0.5 mg boron/100
g, whereas animal foods provide only 0.01 to 0.06 mg of
boron/100 g. Another important source of boron is water,
and the content varies according to geographic location [9].
S0946-672X(18)30156-1
https://doi.org/10.1016/j.jtemb.2018.06.003
It has been known for a long time that B deficiency in soils, leads to depletion of BCCs in fruits and vegetables in the food
supply, was correlated with a high incidence of arthritis [38–40], an inflammatory disease also related to cardiovascular
health [41,42].
Tobacco products contain a plethora of potential toxic molecules, amongst the most cytotoxic of them being nicotine. Diets
enriched in BCCs exhibited a notable risk reduction for cervical cancer, prostate cancer, and also in lung cancer for women
who were heavy smokers [116]. Moreover, the superior natural BCCs intake has been correlated with the most reduced
7lung cancer risks in smoking persons, while the most advanced risk is found in smoking persons with concurrent lack of
hormone replacement therapy (HRT) and low B intake [116].